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Reduced bone mass accrual in mouse model of repetitive mild traumatic brain injury

This study investigates the effects of repetitive mild traumatic brain injury (TBI) on bone mass accrual in a female mouse model. The findings suggest that mild TBI negatively affects the accrual of cortical and trabecular bone mass, potentially due to reduced bone formation and serum insulin-like growth factor 1 (IGF-I) levels.

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Reduced bone mass accrual in mouse model of repetitive mild traumatic brain injury

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  1. Reduced bone mass accrual in mouse model of repetitive mild traumatic brain injury Hongrun Yu, PhD; Jon E. Wergedal, PhD; Charles H. Rundle, PhD; Subburaman Mohan, PhD

  2. Aim • Use female mouse model to evaluate effects of mild traumatic brain injury (TBI) on skeleton. • Relevance • TBI can affect bone by influencing the production/ actions of pituitary hormones and neuropeptides important to bone metabolism regulation.

  3. Methods • Created repetitive mild TBI model. • 95 g drop weight and 1 m drop height. • 18 mice (9 experimental and 9 control). • Measured in vivo bone parameters of total body and specific skeletal tissues 1 and 2 wk after 1st impact. • After 2nd measurement, euthanized mice and collected trunk blood, brain, tibias, and femurs. • Performed brain gene expression analysis, brain histological analysis, and bone strength test.

  4. Results • 2 wk after 1st impact, mice subjected to repetitive mild TBI showed: • Microhemorrhaging. • Astrocytosis. • Increased anti-inflammatory protective actions in brain. • Reduced (28.9%) serum insulin-like growth factor 1 levels. • Significantly reduced bone mass. • Reduced tibial total cortical (7%) and trabecular (27.5%) bone density. • Led to weaker bones.

  5. Conclusions • Repetitive mild TBI exerted significant negative effects on accrual of both cortical and trabecular bone mass in mice. • Reduced bone formation rate. • Reduced serum IGF-I could be one contributing factor for the negative effects of mild TBI on bone formation.

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