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PKG Signalling PowerPoint Presentation
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PKG Signalling

PKG Signalling

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PKG Signalling

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  1. T58 T516 PDK1 PKG PKCa PKG Signalling ? cGMP

  2. eNOS PLCB3 PDE5A GUCY1A3 S23 S1105 S106 S1177 S64 T1122 T58 T516 PDK1 PKG PKCa PKG Signalling ? cGMP

  3. eNOS PLCB3 PDE5A GUCY1A3 S1105 S64 S1177 S23 S106 T516 T1122 T58 PDK1 PKG PKCa PKG Signalling ? cGMP NO

  4. eNOS PLCB3 GUCY1A3 PDE5A S1177 S64 S106 S1105 S23 T516 T58 T1122 PDK1 PKG PKCa PKG Signalling ? cGMP DAG NO Ca2+ IP3

  5. PKG Signalling Substrate Substrate Full Name ProteinType Substrate Phospho- Effect of Kinase All Kinases Phosphatase Short Name Swissprot site Phosphorylation Affecting Affecting Affecting eNOS Endothelial nitric oxide Synthetase P29474 S1177 Phosphorylation increases PKG1 PKACa, synthetase enzymatic activity of PKBa/Akt1, eNOS. PKG1 GUCY1A3 Soluble guanylate cyclase Cyclase Q02108 S64 Phosphorylation inhibits PKG1 PKG1 cyclase activity. PDE5A cGMP phosphodiesterase 5 Phosphodiesterase O76074 S106 Phosphorylation increases PKG1 PKACa, PKG1 PPP1CA phosphodiesterase activity. PKG1 cGMP-dependent protein Protein-serine kinase, Q13976 T58 Phosphorylation increases PKG1 PKCa, PKG1 kinase 1, alpha AGC group, PKG family phosphotransferase activity and affinity for cGMP PLCB3 1-phosphatidylinositol-4,5- Enzyme, phospholipid Q01970 S1105 Phosphorylation inhibits of PKG1 PKG1 bisphosphate phospholipase C, G-protein-activated PLC- phosphodiesterase beta 3 phosphatidylinositol- beta3 activity. specific PLCB3 1-phosphatidylinositol-4,5- Enzyme, phospholipid Q01970 S26 Phosphorylation inhibits of PKG1 PKG1 bisphosphate phospholipase C, G-protein-activated PLC- phosphodiesterase beta 3 phosphatidylinositol- beta3 activity. specific PLCB3 1-phosphatidylinositol-4,5- Enzyme, phospholipid Q01970 T1122 Phosphorylation inhibits of PKG1 PKG1 bisphosphate phospholipase C, G-protein-activated PLC- phosphodiesterase beta 3 phosphatidylinositol- beta3 activity. specific PKG1 cGMP-dependent protein Protein-serine kinase, Q13976 T516 Phosphorylation increases ? ? kinase 1, alpha AGC group, PKG family phosphotransferase activity.