Disruption of LRP6 in osteoblasts blunts the bone anabolic activity of PTH

Oct 31, 2014

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Disruption of LRP6 in osteoblasts blunts the bone anabolic activity of PTH. Osteoscoop - Issue N°334 – April 2014. Mesenchymal stem cell. Preosteoblast. Osteoblast. +. -. Bone formation. Apoptotic osteoblast. PTH. Mesenchymal stem cell. Preosteoblast. Osteoblast. +. -.

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Disruption of LRP6 in osteoblasts blunts the bone anabolic activity of PTH

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Disruption of LRP6 in osteoblasts blunts the bone anabolic activity of PTH Osteoscoop - Issue N°334 – April 2014
Mesenchymal stem cell Preosteoblast Osteoblast + - Bone formation Apoptotic osteoblast PTH
Mesenchymal stem cell Preosteoblast Osteoblast + - Bone formation Apoptotic osteoblast PTH PTH PTH PTH1R LRP6 P P P b-Catenin b-Catenin Nucleartargets
Mesenchymal stem cell Preosteoblast Osteoblast + - GaS Bone formation AC PKA Apoptotic osteoblast PTH PTH PTH PTH1R LRP6 P P P b-Catenin b-Catenin cAMP Nucleartargets