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Vascular Disease Prevention

Systemic cholesterol ↓. Peripheral cholesterol ↓. Billary Choleserol (~75%). Dietary Choleserol (~25%). Ezetimibe. LDL receptors↑. NPC1L1. Liver. JNK↑. NPC1L1. Hepatic ApoB 100 ↓. Akt ↓. Intestinal ApoB 48 ↓. Bile acids. VLDL ↓. Fatty liver ↓. Entero-hepatic

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Vascular Disease Prevention

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  1. Systemic cholesterol ↓ Peripheral cholesterol ↓ Billary Choleserol (~75%) Dietary Choleserol (~25%) Ezetimibe LDL receptors↑ NPC1L1 Liver JNK↑ NPC1L1 Hepatic ApoB 100 ↓ Akt ↓ Intestinal ApoB 48 ↓ Bile acids VLDL ↓ Fatty liver ↓ Entero-hepatic circulation ↓ Improving NAFLD NPC1L1 Micellar cholesterol LDL-C↓, CM↓, TG↓, HDL-C ↑ Glucose↓ Vascular Disease Prevention Insulin sensitivity ↑ intestine Improving Type 2 diabetes TG ↓, HDL-C ↑ Improving Metabolic syndrome Improving Dyslipidemia

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