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How do Molecules form Living, Moving, Reproducing Cells?

How do Molecules form Living, Moving, Reproducing Cells? . 1683, Leeuwenhoek: “An unbelievably great company of living animalcules, a-swimming more nimbly than any I had ever seen up to this time. The biggest sort bent their body into curves in going forwards.".

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How do Molecules form Living, Moving, Reproducing Cells?

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  1. How do Molecules form Living, Moving, Reproducing Cells? 1683, Leeuwenhoek: “An unbelievably great company of living animalcules, a-swimming more nimbly than any I had ever seen up to this time. The biggest sort bent their body into curves in going forwards." 1988, Francis Crick: “Every living cell and every biological macromolecule is the end result of natural selection, which had acted over billions of generations to produce complexity from ordinary physics and chemistry”

  2. Molecular Hierarchy of the Cell → → Proteins (Enzymes and Motors) Protein Assemblies (Cytoskeletal Filaments) DNA

  3. Moving Parts: Motor Proteins on Polymer Tracks

  4. Cellular Machines based on MTs and motors The Cilium The Mitotic Spindle

  5. “The Cell as a Collection of Protein Machines: Preparing the Next Generation of Molecular Biologists”. (Alberts, B (1998)Cell 92: 291). Assembly and Function? Biochemistry, Genetics, Microscopy, Quantitative Modeling.

  6. Bacterial (prokaryotic) Cells.

  7. Locomoting Eukaryotic Cells.

  8. Mechanism of Eukaryotic Cell Locomotion.

  9. Scanning E.M. of the leading edge.

  10. E.M. of Actin Filaments in the Leading Edge.

  11. Ribbon Diagram of Atomic Structure of Actin.

  12. Structure of Actin Filaments – helical symmetry.

  13. Actin Filament Assembly and Force Production.

  14. Actin filament polymerization drives Listeria Motility.

  15. Listeria Motility Julie Theriot Stanford University Medical School

  16. Eukaryotic Cell Reproduction; Mitosis and Cell Division.

  17. Sullivan Lab Mitosis studied inthe Drosophila melanogaster Syncytial Embryo GFP-tubulin; histone-RFP; 480 seconds total time (Ingrid Brust-Mascher)

  18. MOTOR PROTEINS AND MICROTUBULE-BASED MACHINES. Mitosis in Drosophila Embryos.

  19. Metaphase Anaphase A Anaphase B Mechanism of Mitosis.

  20. Cytokinesis in Animal Cells.

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