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The innate immune system as a window into sponge-microbe interactions

The innate immune system as a window into sponge-microbe interactions. Jo Bayes Sandie Degnan School of Biological Sciences UQ. Questions. How does Amphimedon acquire its symbionts ? How does the bacterial community of Amphimedon change throughout its lifecycle?

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The innate immune system as a window into sponge-microbe interactions

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  1. The innate immune system as a window into sponge-microbeinteractions Jo Bayes Sandie Degnan School of Biological Sciences UQ

  2. Questions • How does Amphimedon acquire its symbionts? • How does the bacterial community of Amphimedonchange throughout its lifecycle? • How does innate immune gene expression change throughout Amphimedon’slifecycle?

  3. Ancient, abundant, invisible life forms

  4. Microbial-metazoan interactions • Marine bacteria - freeliving • - pathogenic • - symbiotic • Bacteria 3.5 bya • Sponges 650 mya

  5. Amphimedonqueenslandica • Heron Island • Indo-Pacific distribution • Hermaphroditic spermcast spawner • Broods embryos • First Poriferan genome Srivastavaetal. 2010 • Alpha - proteobacteria bacteria sequenced

  6. Questions • How does Amphimedon acquire its symbionts? • How does the bacterial community of Amphimedonchange throughout its lifecycle? • How does innate immune gene expression change throughout Amphimedon’slifecycle?

  7. Microbial -metazoan interactions • Symbiont transmission • Vertical - Poribacteria • Horizontal

  8. Questions • How does Amphimedon acquire its symbionts? • How does the bacterial community of Amphimedonchange throughout its lifecycle? • How does innate immune gene expression change throughout Amphimedon’slifecycle?

  9. Microbial communities Least similar Most similar

  10. Questions • How does Amphimedon acquire its symbionts? • How does the bacterial community of Amphimedonchange throughout its lifecycle? • How does innate immune gene expression change throughout Amphimedon’slifecycle?

  11. Innate Immunity: A first line recognition system • Vertebrates • Innate and Adaptive • Memory cells • Invertebrates • Innate • Alternative adaptive ?

  12. Innate Immunity: A first line recognition system • Pattern Recognition Receptors • Microbial Associated Molecular Patterns Gram positive Gram negative

  13. Amphimedoninnate immune genes of interest

  14. Amphimedoninnate immune gene expression

  15. Conclusions • Symbiotic microbes acquired via vertical and horizontal transmission • Symbiotic from transitory community • Immune genes induced or developmental? • Benthos • Feeding • Thank you... • Sandie Degnan • Bernie Degnan • (School of Biological Sciences, UQ) • Phil Hugenholtz • (Australian Centre of Ecogenomics) • Degnan lab • http://web.me.com/degnanlab1/DegnanLab/Home.html • http://ecogenomic.org/users/jo-bayes

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