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Genetics analysis and reproduction: What is preimplanation genetic diagnosis?

Genetics analysis and reproduction: What is preimplanation genetic diagnosis? Personal Genetics Education Project (pgEd) Harvard Medical School - Wu Lab www.pged.org Complete lesson plans at: www.pged.org/curricula. Discussion Questions:.

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Genetics analysis and reproduction: What is preimplanation genetic diagnosis?

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  1. Genetics analysis and reproduction: What is preimplanation genetic diagnosis? Personal Genetics Education Project (pgEd) Harvard Medical School - Wu Lab www.pged.org Complete lesson plans at: www.pged.org/curricula

  2. Discussion Questions: • If you could choose specific traits or qualities that you would want your child to have, what would you choose? Why? • Are there any you would not want your child to have? What are they? Why?

  3. personal genetics educationproject • PGD is a method to test for certain genetic traits in an embryo, almost always for genetic disease. • An embryo is created via in vitro fertilization. • Genetic testing occurs when embryo is 2-4 days old, typically at the 8-cell stage. • A single cell is removed and tested. • The results of testing are used to decide which embryos, • if any, to implant in prospective mother’s uterus. What is preimplantation genetic diagnosis (PGD)?

  4. personal genetics educationproject PGD being performed on a 3-day old embryo Image via http://www.obgyn.net/Frontiers_In_Reproductive_Medicine/images/PGD.gif

  5. personal genetics educationproject Real Families impacted by PGD: Molly and Adam Nash and the Hashmis http://news.bbc.co.uk/olmedia/955000/images/_955928_nash150.jpg http://www.telegraph.co.uk/news/graphics/2007/08/01/nivf101.jpg

  6. personal genetics educationproject aneuploidy autosomal disorders chromosomal rearrangement X-linked diseases non-medical sex selection avoid adult-onset disease What % of IVF clinics provide testing for the following reasons? HLA typing HLA typing w/o single gene test Select for a disability

  7. personal genetics educationproject Public attitudes regarding acceptable uses of PGD: fatal HLA match adult onset disease sex Intelligence/ strength

  8. Opinion poll: What role, if any, should the US government play in regulating preimplantation genetic diagnosis (PGD)? Wants a total ban on PGD Supports no government regulation Thinks government should regulate ethics only Supports government regulation of safety and quality Believes government should regulate safety, quality and ethics

  9. Discussion Questions • What are the potential opportunities and challenges of PGD? • Now that we’ve discussed the issue a bit, did you change your opinion about whether you’d want to choose certain traits for your child? • If your parents used this on you - should they tell you? Or is it no big deal? • Do we need rules to guide how this is used? If yes, what sort of rules? Whose job would it be to enforce them? personal genetics educationproject

  10. For more information, please visit us at www.pged.org personal genetics educationproject

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