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Hypersensitivity

Hypersensitivity.  Hypersensitivity – Exaggerated immune response that have deleterious effects and causes damage to the individual.  Anaphylaxis – an immediate hypersensitivity reaction triggered by mast cell degranulation . Can be local or systemic.

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Hypersensitivity

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  1. Hypersensitivity Hypersensitivity – Exaggerated immune response that have deleterious effects and causes damage to the individual. Anaphylaxis – an immediate hypersensitivity reaction triggered by mast cell degranulation. Can be local or systemic. Prophylaxis - measures designed to preserve health and prevent the spread of disease; protective or preventive treatment. Can be: immediateor delayed(DTH)

  2. Hypersensitivity Classification based on immune response: Type I – IgE-Mediated Type II – Antibody-Mediated Cytotoxic Type III – Immune Complex-Mediated Type IV – Delayed-Type (DTH)

  3. Hypersensitivity Type I – IgE-Mediated Hypersensitivity cross-linking of IgE to mast cells and basophils results in systemic and local anaphylaxis

  4. Type I – IgE-mediated Hypersensitivity

  5. Type I – IgE-mediated Hypersensitivity Allergens – antigens that induce type I hypersensitivity

  6. Type I – IgE-mediated Hypersensitivity IgE cross-linkage initiates degranulation

  7. Type I – IgE-mediated Hypersensitivity Mediators of Type I Reactions: Primary Histamine Serotonin Chemotactic factors Proteases Secondary Platelet-activating factor Leukotrienes Prostaglandins Bradykinin Cytokines

  8. Type I – IgE-mediated Hypersensitivity systemic anaphylaxis local anaphylaxis Allergic rhinitis Asthma Food allergies Atopic dermatitis Treatment of Type I hypersensitivity Antihistamines Cromolyn sodium Theophylline Epinephrine Cortisone

  9. Hypersensitivity Type II – Antibody-Mediated Cytotoxic Hypersensitivity Antibodies mediate destruction via complement or ADCC

  10. Type II Hypersensitivity Type II – Antibody-Mediated Cytotoxic Hypersensitivity

  11. Type II Hypersensitivity

  12. Hypersensitivity Type III – Immune Complex-Mediated Hypersensitivity Antibody-antigen complexes activate complement

  13. Type III Hypersensitivity Immune Complex-Mediated Hypersensitivity

  14. Hypersensitivity Type IV – Cell-Mediated Hypersensitivity Cytokine release activate macrophages and TC cells

  15. Type IV - Hypersensitivity

  16. Type IV - Hypersensitivity

  17. Type IV - Hypersensitivity

  18. Type IV Hypersensitivity

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