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Impact of GSNO and Cold Treatment on Cyclin A, Cyclin B, and E2F1 Activity

This study investigates the effects of cold treatment and GSNO on various cell cycle regulators such as Cyclin A, Cyclin B, CDC2, and E2F1. We analyze the expression changes through fold change metrics across multiple conditions, including those with genetic mutations in E2F1 and PLK. The results reveal significant interactions between cold stress and GSNO treatment, influencing cell cycle dynamics and regulatory pathways crucial for cellular responses to environmental changes. Keywords include Cyclins, E2F1, Cold Treatment, GSNO.

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Impact of GSNO and Cold Treatment on Cyclin A, Cyclin B, and E2F1 Activity

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  1. GSNO GSNO Cold Cyclin A Cold Cyclin B Cold CDC2 Cold PLK mut PLK 2.0 GSH Cold E2F1 Anti-E2F1 Cold CDC2 GSNO Cold CDC6 mut E2F1 PBS GSNO GSH PBS 1.8 1.6 1.6 1.4 1.4 Fold change 1.2 1.2 1.0 Fold change 1.0 0.8 0.8 0.6 0.6 A B Cold Cyclin A Cold Cyclin B 0.4 Cold CDC2 Cold PLK mut PLK Cold CDC2 Cold CDC6 Cold E2F1 Anti-E2F1 GSNO mut E2F1 GSH GSNO CDE/CHR Probe GSH E2F Probe GSNO GSNO C D

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