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A Puneet Group Presentation

A Puneet Group Presentation. Vitiligo - A social stigma. Light! Did you say Light! The patch looks lovely bright Soon the white patch Grows and spreads The sun makes it A little red, how can Vitiligo Harmless, not even skin deep Can cause a trauma so deep?. VITILIGO.

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A Puneet Group Presentation

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  1. A Puneet Group Presentation

  2. Vitiligo - A social stigma Light! Did you say Light!The patch looks lovely brightSoon the white patchGrows and spreadsThe sun makes itA little red,how can VitiligoHarmless, not even skin deepCan cause a trauma so deep?

  3. VITILIGO • Chronic skin disease occurring worldwide in about 1% of the population, mostly between the age of 10-30 • White spots occur when the skin no longer forms melanin (pigment that determines the color of your skin, hair, and eyes) • White patches of irregular shapes begin to appear on skin • Total absence of melanocytes microscopically

  4. CLINICAL FEATURES • Totally amelanoticmacule (patch) surrounded by normal skin • Vitiligomacules characteristically have fairly discrete margins and they are round, oval or linear in shape • Lesions enlarge centrifugally over time, but the rate may be slow or rapid • Vitiligomacule patches ranges from millimeter to centimeter in size

  5. DISTRIBUTION PATTERN OF VITILIGO

  6. Sub types of VitiligoDiffer by anatomical location, and size of lesions

  7. Vitiligo cause- melanocyte destruction • Stress to the skin in form of wound, burn, excessive sun exposure or contact with bleaching phenol • Differential gene expression among melanocytes • Inflammatory infiltrate of T cells & macrophages • 4. Further induce melanocyte apoptosis

  8. Why is the treatment important??? • Vitiligo - not harmful medically, but emotional and psychological effects can be devastating. • Affects self-esteem. • Women, are sometimes discriminated against in marriage. • Developing vitiligo after marriage can be grounds for divorce. • People suffering from vitiligo feel embarrassed, depressed, or worried about other people’s reaction.

  9. The primary goal of Vitiligo therapy is to repigment the affected skin. However, it is not always possible. In such cases , depigmentation is the only available option

  10. Where de-pigmentation therapy required

  11. List of depigmentingagentS

  12. When de-pigmentation is the only option... COMPOSITION:-MONOBENZONE USP…..20% W/W CREAM BASE…………..Q.S.

  13. MONOBENZONE • Monobenzyl ether of hydroquinone (MBEH) • Chemical Name: P- (Benzyloxy) - Phenol • Acts as a skin sensitizer • Topical application decreases the excretion of melanin from melanocytes in animal • Depigmentation spreads to distant sites unexposed to Monobenzone • Progressive systemic reaction against melanocytes

  14. Mechanism of action INHIBITS Tyrosinase

  15. monobenzone is the most widely used depigmenting agent

  16. LIMITATIONS OF OTHER DEPIGMENTING AGENTS

  17. Efficacy of monobenzone therapy Residual patches of vitiligo affecting more than 70% of her skin surface Depigmentation after topical application of 20% Monobenzone daily after8 months Pigment Cell Melanoma Res. 22; 42-65. REVIEW ARTICLE Update on skin pigmentation therapies in vitiligo. Rafael Falabella and Maria I. Barona. Page No. 11

  18. Administration: • Apply a thin layer of to the normal coloured skin area which requires depigmentation usually two to three times daily or as directed by physician. There is no recommended dose for children under 12 years of age except under the advice and supervision of a physician. • It may take up to 4 months before the full benefit of this drug takes effect. Once the desired skin colour is achieved, this medication is applied only as needed to maintain the new skin colour (usually 2 times a week).Use cream regularly to get the most benefit from it. Inform the doctor if your condition persists or worsens after 4 months.

  19. Side Effects of Monobenzone • Mild burning, • Irritation, • Redness, • Cracking, or • Peeling of the treated skin may occur. If any of these effects persist or worsen, doctor needs to be informed.

  20. precautions • This medication is for use on the skin only. cream should be applied with a patch test for 48 h to detect hypersensitivity. • Avoid application of to the eyelids and areas close to the eye. • Avoid getting this product in your eyes or on the inside of your nose or mouth. If the cream is accidentally applied in these areas, flush with plenty of water. • After using this medication, the skin will be permanently affected and sensitive to sunlight. Avoid prolonged exposure to sunlight. Always use a sunscreen of SPF 15 or greater, and wear protective clothing when outdoors.

  21. Albaquin treatment effects • As a depigmenting agent, Monobenzone lightens up the pigmented areas and matches them with the white patches arisen out of Vitiligo skin disorder and can provide following effects to the patients : • Permanently depigmentedskin • Produce an even tone • Match the skin around the vitiligo patches to a uniform light colour • Create a feeling of normalcy for the patient

  22. Brings about permanent de pigmentation • Only drug used worldwide as a depigmentation therapy for vitiligo • Safe and well tolerated • No toxicity to liver or kidney • Permanently lightens skin IDEAL THERAPY FOR UNIFYING SKIN COLOUR

  23. FOR FURTHER DETAILS CONTACT PUNEET LABORATORIES PVT.LTD. 605 Raheja Plaza , B wing, LBS Road, Ghatkopar (West), Mumbai 400086, India. TEL. 91-22-61367000 Division Head : Mrs. RashmiJain Customer Care : 18002096261 E-MAIL : customercare@puneetlabs.com VISIT US AT: www.albaquin.com

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