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"Expression of miR-21, miR-106b, and let-7a in Gastric Cancer: A Comparative Study"

This study investigates the expression levels of mature microRNAs (miR-21, miR-106b, and let-7a) in gastric cancer tissues compared to normal tissues. We analyzed concentration data (amol/μl) from both cancer patients and healthy controls, assessing the significance of differences between pre-operative and post-operative samples. Key findings indicate the potential diagnostic and prognostic value of these microRNAs, with notable AUC values for sensitivity and specificity in identifying cancer.

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"Expression of miR-21, miR-106b, and let-7a in Gastric Cancer: A Comparative Study"

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  1. 40 △ miR-21 × miR-106b ■ let-7a 30 Ct value 20 10 0 Log concentration 1 -5 -4 -3 -2 -1 0

  2. 2.50E-1 A: miR-21 8.00E-1 B: miR-106b 2.00E-1 1.00E+0 1.00E+0 1.00E+0 6.00E-1 1.50E-1 Concentrations (amol/μl) 4.00E-1 1.00E-1 1.00E-1 1.00E-1 1.00E-1 Concentrations (amol/μl) 5.00E-2 2.00E-1 1.00E-2 1.00E-2 1.00E-2 0 0 cancer cancer cancer cancer (n=34) cancer (n=34) cancer (n=34) control (n=15) control (n=15) control (n=15) control control control 1.00E-3 1.00E-3 1.00E-3 1.50E-1 C: let-7a 1.25E-1 1.00E-1 7.50E-2 Concentrations (amol/μl) 5.00E-2 2.50E-2 0

  3. 1.20E-1 1.00E-1 p=0.013 p=0.022 8.00E-2 1.00E-1 6.00E-2 8.00E-2 4.00E-2 6.00E-2 2.00E-2 miR-106bConcentrations (amol/μl) miR-21Concentrations (amol/μl) 0 4.00E-2 2.00E-2 0 Pre-Op 1 month post -Op Pre-Op 1 month post -Op

  4. 2.00E-1 5.00E-1 3.00E-1 2.00E-2 miR-17-5pConcentrations (amol/μl) miR-21Concentrations (amol/μl) miR-106aConcentrations (amol/μl) 5.00E-2 3.00E-2 2.00E-3 5.00E-3 3.00E-3 cancer patient cancer patient cancer patient controls controls controls 1.00E+0 1.00E+0 1.00E-1 1.00E-1 1.00E-2 1.00E-2 let-7aConcentrations (amol/μl) miR-106bConcentrations (amol/μl) 1.00E-3 1.00E-3 1.00E-4 1.00E-4 cancer patient cancer patient controls controls

  5. 1.0 0.8 0.6 0.4 0.2 0 0 0.2 0.4 0.6 0.8 1.0 Sensitivity miR-106b AUC=0.721 1-Specificity

  6. 1.0 0.8 0.6 0.4 0.2 0 0 0.2 0.4 0.6 0.8 1.0 Sensitivity miR-106a/let-7a AUC=0.879 1-Specificity

  7. Sensitivity Sensitivity miR-17-5p AUC=0.626 miR-21 AUC=0.673 1-Specificity 1-Specificity Sensitivity miR-106a AUC=0.634 1-Specificity

  8. Sensitivity Sensitivity miR-17-5p/let-7a AUC=0.784 miR-21/let-7a AUC=0.753 1-Specificity 1-Specificity Sensitivity miR-106b/let-7a AUC=0.776 1-Specificity

  9. Table 1 Expression of mature miRNAs in gastric cancer tissue versus those in normal tissue

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