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Conditional inactivation of Noggin in the postnatal skeleton causes osteopenia

Conditional inactivation of Noggin in the postnatal skeleton causes osteopenia. Osteoscoop - Issue N°243 – June 2012. Noggin. BMP-2. Smad. +. Sclerostin. Osteoblast. Lower weight. Shorter femoral length. Generalized osteopenia. Noggin D /+. Noggin D /-. Noggin. BMP-2. Smad. +.

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Conditional inactivation of Noggin in the postnatal skeleton causes osteopenia

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  1. Conditional inactivation of Noggin in the postnatal skeleton causes osteopenia Osteoscoop - Issue N°243 – June 2012

  2. Noggin BMP-2 Smad + Sclerostin Osteoblast

  3. Lower weight Shorter femoral length Generalized osteopenia NogginD/+ NogginD/- Noggin BMP-2 Smad + Sclerostin Osteoblast

  4. Lower weight Noggin Low bone formation Wnt signaling BMP-2 Shorter femoral length Smad + Sclerostin Generalized osteopenia Osteoblast NogginD/+ NogginD/-

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