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Choline/NAA Spatial Variation

Explore the spatial variation of Cho/NAA ratio for necrosis/disease discrimination using MRI scans from patients at the University of Arizona Medical Center, indicating potential diagnostic value. Detailed findings highlight changes in ratios near the center versus periphery of lesions over time.

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Choline/NAA Spatial Variation

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  1. Choline/NAA Spatial Variation Lars Ewell Radiation Oncology University of Arizona Medical Center 1/25/08

  2. Cho/NAA Spatial Variation Cho/NAA has potential for necrosis/disease discrimination Weybright et al., Neuroradiology (2004) 46: 541–549

  3. Patient 1: Scanned 3/23/07 S26 S46

  4. Patient 1, Cho/NAA 3/23/07 • Highest ratio near center of disease/radiation. • Dark blue not zero, ambiguous, indeterminate spectra.

  5. Patient 1, Cho/NAA 5/8/07 • Highest ratio moved posterior relative to 3/23/07 spectra. • Dark blue not zero, ambiguous, indeterminate spectra.

  6. Patient 1: Row and Columns 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

  7. Central Increase going from Inferior to Superior Slice: Columns 6, 7, 8 • Peripheral Decrease going from Inferior to Superior Slice: Columns 5, 10, 11

  8. Similar behavior for row number 12

  9. Closer to lesion, different behavior

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