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Lack of Radioprotection by MEK Inhibition in U251 Cells

U251 cells were insensitive to radiation when P-ERK1/2 was downregulated with 2 µM of MEK inhibitor, U0126. The inhibitor's effectiveness was confirmed by reducing colony formation by 20 µM U0126. Despite this, no synergistic effect with radiation was found at this concentration. Therefore, MEK signaling does not appear to play a role in mediating radioprotection in these cells.

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Lack of Radioprotection by MEK Inhibition in U251 Cells

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  1. Supplementary Figure Supplementary Figure U251 cells were not sensitized to radiation by downregulation of P-ERK1/2 with 2 µM of MEK inhibitor, U0126. The activity of the inhibitor was verified by the reduction of colony formation by 20 µM U0126. However, even at this concentration a synergistic effect with radiation was not observed. Thus signalling via MEK does not seem to mediate radioprotection in these cells.

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