1 / 13

Addressing Colon Cancer in Alaska: Challenges, Screening, and Treatment Options

Colon cancer remains a significant health issue in Alaska, with over 50 new cases reported annually among Alaska Natives. Risk factors include age, family history, and genetic predisposition. Screening methods like FOBT, sigmoidoscopy, and colonoscopy face challenges, particularly in diagnosing gastrointestinal bleeding. Accurate staging is crucial, ranging from localized (Stage I) to distant metastases (Stage IV). While surgery is the primary treatment, chemotherapy and radiation therapy play essential roles, especially in rectal cancers. Understanding these factors is vital for improving patient outcomes.

pravat
Télécharger la présentation

Addressing Colon Cancer in Alaska: Challenges, Screening, and Treatment Options

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. COLON CANCER A MAJOR ISSUE IN ALASKA

  2. A common malignancy • 200,000 cases in the U. S. in 2008 • Greater than 50 new cases each year in Alaska Natives

  3. RISK FACTORS • Age • Family history • Genetic predisposition • Adenomatous polyps • History of other gastrointestinal malignancies

  4. Screening • FOBT • Problematic in our patient population because of H. pylori • Cannot differentiate upper from lower bleeds • A new test being studied possibly can • Sigmoidoscopy • Colonoscopy

  5. Diagnosis • Tissue biopsy

  6. Staging • I confined to the mucosa • II into the muscularis • III involving the lymph nodes • IV distant metastases

  7. Special considerations • Colon versus Rectum • A different approach for rectal cancer both before and after surgery

  8. Treatment • Surgery is the primary curative therapy • Pre-op chemotherapy-radiotherapy for rectal cancer unless the lesion is superficial • For patients with metastastic disease who are or may soon become obstructed

  9. CEA • Good to have a baseline CEA, for both follow up and to follow for recurrence or progression

  10. Chemotherapy • Adjuvant • For Stage III • For high risk stage II (T4 N0) • Obstruction • Perforation • circumferential • For pre-op in rectal lesions, then post op

  11. Radiation for rectal cancers • Pre-Op • Stage III • High risk stage II • After trans-anal resection of lesions greater than T2

  12. Agents • FOLFOX • XELOX • Irinotecan • Avastin • Cetuximab • Penitumumab

  13. Unusual side effects • Hand-Foot syndrome • Cold-induced neuropathy • Cholera syndrome • Skin rash • Perforation (bowel, lung, wound) • Accelerated hypertension

More Related