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Effect of CFMTI on L-Glutamate-Induced Ca2+ Mobilization

Investigating the impact of CFMTI at 3 to 30nM on intracellular Ca2+ mobilization induced by L-glutamate in CHO cells expressing human mGluR1a. Results presented as % of 1mM L-glutamate response.

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Effect of CFMTI on L-Glutamate-Induced Ca2+ Mobilization

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  1. 0 nM CFMTI 3 nM CFMTI 10 nM CFMTI 30 nM CFMTI 125 100 75 Ca2+moblization (% of 1 mM L-Glu response) 50 25 0 -9 -8 -7 -6 -5 -4 -3 -2 Log [L-glutamate] (M) Supplemental Figure 2. Effect of CFMTI on concentration-response curves for L-glutamate-induced increases in intracellular Ca2+ mobilization. Concentration response curves for L-glutamate in the absence or presence of CFMTI at 3 to 30 nM in CHO cells expressing human mGluR1a. Results are expressed as a percentage of the response to 1 mM L-glutamate, and they are mean  S.D. of the representative experiment in three independent experiments performed in triplicate. Ca2+ mobilization assay were carried out as described in Methods.

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