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Flow Restrictions and Fluid Turbulence in Microfluidic Channels

Flow Restrictions and Fluid Turbulence in Microfluidic Channels. By Joseph M. Clift. Outline. Introduction Gate Design and Fabrication of Gated Channels Fabrication of Mixers Conclusions and Future Directions. Why is it important?.

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Flow Restrictions and Fluid Turbulence in Microfluidic Channels

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  1. Flow Restrictions and Fluid Turbulence in Microfluidic Channels By Joseph M. Clift

  2. Outline • Introduction • Gate Design and Fabrication of Gated Channels • Fabrication of Mixers • Conclusions and Future Directions

  3. Why is it important? • Microfluidic devices can be utilized for a wide range of applications such as • Biosensors1,2 • Microreactors1,2 Image from http://thebigone.stanford.edu/

  4. Fabrication of Gates • Gated channels are produced on Macromedia Freehand™. • The finished drawings are then printed on a transparency from high resolution laser printer and cut to fit into the petri dishes.

  5. Nonlithographic Fabrication Method

  6. Microfluidic Gates 200mm 200mm Image taken of three microchannels of distances 165mm, 195mm, and 205mm at 34x. Image of 195mm microchannel at 50x.

  7. Gate Dimensions

  8. Microfluidic Mixers • Small cross sections and large linear flow velocity leads to laminar flows • Mixing is essential for biosensors (labeling of samples) and microreactors • Active mixers – moving stirrers • Passive mixers – no moving parts, the cannel geometry generates intertwining flows

  9. Nonlithographic Fabrication of Micromixers

  10. 100 mm 400 mm Observations of mixing channels

  11. Conclusions • Nonlithographic fabrication is a facile and low-cost alternatives for expedient prototyping. • Microgate fabrication exceeded twice the resolution of the printers we used. • Nonlithographic methods allow for the fabrication of circular channels with patterned walls. • Spiral grooves along the walls of micromixers significantly increases the mixing efficiency.

  12. Future Directions • Evaluate fluid flow through the microgates • Model the fluid flow in the spiral-grooved micromixers

  13. References • Trinidad National Institute of Higher Education compiler. 2001 [cited 2007 Jul 24]. Make Way for Microfluidics! Trinidad: NIHERST. Available from: http://www.niherst.gov.tt/scipop/sci-bits/microfluidics.htm • Whatis.com compiler. 2001 [cited 2007 Jul 24]. Microfluidics. Needham, MA: Whatis.com. Available from: http://whatis.techtarget.com/definition/0,,sid9_gci526632,00.html • Stephen R. Quake compiler. 2005 [cited 2007 Aug].. Stanford, CA: Quake Group homepage. Available from: http://thebigone.stanford.edu/

  14. Dr. Vullev Marlon Thomas Connie Chong Brent Millare Amy Ferriera Elizabeth Zielins BRITE administration and members Acknowledgements

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