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Effects of FSK and IBMX on pCREB and Tubulin in PMNs Migration Study

This study investigates the impact of forskolin (FSK) and IBMX on phosphorylated cAMP response element-binding protein (pCREB) levels and tubulin in polymorphonuclear leukocytes (PMNs). Utilizing densitometry, we analyze the protein expression of pCREB and tubulin upon exposure to different concentrations of FSK and IBMX. Our results highlight the modulation of PMN migration by these compounds, signifying a potential pathway for therapeutic intervention in inflammatory responses.

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Effects of FSK and IBMX on pCREB and Tubulin in PMNs Migration Study

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  1. 3.5 B ) 3 tubulin - 2.5 * β / * 2 pCREB Normalized Densitometry 1.5 SE - 1 (Mean +/ 0.5 4 4 4 0 Medium FSK (10uM) IBMX (1mM) 90 * C * 80 Migration * 70 (%) 60 50 PMNs 40 of Transendothelial 30 20 10 12 9 9 12 0 Medium IL - 8 10ng/mL FSK 10uM + IL - 8 IBMX 1mM + IL - 8 A IBMX 1mM FSK 10uM Medium 55 kDa IB pCREB 55 kDa tubulin IB* Figure S1

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