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Learn about neuroglia cells like astrocytes, oligodendrocytes, and microglia that play crucial roles in maintaining the nervous system. Explore demyelination disorders such as Multiple Sclerosis and understand neuron anatomy and membrane potential dynamics.
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Neuroglia • Astrocytes • Largest and most numerous • Maintain blood-brain barrier • Isolates CNS from circulation • Capillaries impermeable • Repair damaged neural tissue
Neuroglia cont… • Oligodendrocytes • Coats axons with myelin • Nodes of Ranvier • Parts of axon with no myelin • Internodes • Parts of axon with myelin • Myelin increases speed of action potential
Neuroglia cont… • Microglia • Engulf wastes and pathogens
Neuroglia cont… • Ependymal Cells • Produces cerebrospinal fluid
Neuroglia cont… • Satellite Cells • Support cell bodies • Schwann Cells • Covers axons—called neurilemma
Demyelination Disorders • Demyelination • Progressive destruction of myelin • Inflammation • Axon Damage • Scarring of neural tissue • Gradual loss of sensation and motor control • Numbness and paralysis
Disorders cont… • Multiple Sclerosis (MS) • Optic nerve, brain and spinal cord affected • Partial loss of vision • Problems with speech, balance and motor coordination
Neuron Anatomy • Neuron cell bodies—gray matter • Located in ganglia of PNS • White matter—bundles of axons • Called nerves
Membrane Potential • Polarized—resting cell membrane • Resting Potential—membrane potential of resting neuron • -70mV • More negative ions inside than out of neuron
Potential cont… • Depolarization • Shift membrane potential towards positive • Ex: 0 mV
Potential Cont… • Hyperpolarization • Shift membrane potential towards more negative • Ex: - 80 mV
Potential cont… • Action Potential • Triggered by depolarization • Membrane potential must reach threshold • -60 mV
Potential cont… • Repolarization • Return to resting potential