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Conserved Motifs in PTP1B Tertiary Structure

Discover core structures and surface loops in the highly conserved PTP1B domain through a ribbon diagram showcasing motifs' positions. Explore more at ptp.cshl.edu & science.novonordisk.com/ptp

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Conserved Motifs in PTP1B Tertiary Structure

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  1. IVMxT (M6) KCxxYWP (M7) WPDxGxP (M8) TxxD FWxMxW (M5) QTxx QYxF (M10) PxxV HCSAGxGRTG (M9) IAxQGP (M4) DxxRVxL (M2) NxxKNRY (M1) DYINA (M3) Core structures within the PTP domain are highly conserved and surface loops between secondary structure elements are least conserved Ribbon diagram indicating the position of conserved motifs (M1-M10) within the tertiary structure of PTP1B (blue - most conserved; red - least conserved). http://ptp.cshl.edu & http://science.novonordisk.com/ptp Andersen et al Mol. Cell. Biol. 2001

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