'Qtl' diaporamas de présentation

Meeting Consumer Demands through Genetic Selection: The NCBA Carcass Merit Project

Meeting Consumer Demands through Genetic Selection: The NCBA Carcass Merit Project. Dan W. Moser on behalf of the CMP Team. Project Team. Principal Investigators: Dr. Michael Dikeman, Kansas State University Shear Force Measurement, Sensory Panel Dr. John Pollak, Cornell University

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Genetic architecture of behaviour

Genetic architecture of behaviour. Genetic architecture of behaviour. How many QTL? What is the average effect size of a QTL? How do the QTL act? What is the molecular basis of QTL action?. OFA App.- John & Gene. OFA/OFD bar graph. (From DeFries, Gervais and Thomas, 1978). OFA line graph.

628 views • 54 slides

Reverse genetics: Quantitative Trait Locus (QTL) mapping Association mapping

Reverse genetics: Quantitative Trait Locus (QTL) mapping Association mapping. Integrating Mendelian and Quantitative Genetics using molecular techniques. Allele A2. Allele A1. 12. 11. 22. 22. 11. 22. 12. 11. 22. 12. Quantitative trait. 16. 28. 40. 52. 64. 76. 88. Height.

1.09k views • 51 slides

Talk Outline

MicroArray Evolution: expression to mapping and back again Justin Borevitz Salk Institute naturalvariation.org. MicroArray Evolution: expression to mapping and back again Justin Borevitz Salk Institute naturalvariation.org. Talk Outline. Natural Variation in Light Response

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QTL Mapping

QTL Mapping. Quantitative Trait Loci (QTL): A chromosomal segments that contribute to variation in a quantitative phenotype. Maize Teosinte tb-1 / tb-1 mutant maize. Mapping Quantitative Trait Loci (QTL) in the F2 hybrids between maize and teosinte.

1.66k views • 39 slides

QTL analysis / Mutagenesis

Genetic basis of atherosclerotic organ damage: From animal genetics to human cohorts. QTL analysis / Mutagenesis. atherosclerosis renal damage HDL cholesterol PLTP activity. candidate genes. functional studies. functional studies. Human populations. Principle of QTL analysis (1).

582 views • 39 slides

what is the goal of QTL study?

Dimension Reduction for Mapping mRNA Abundance as Quantitative Traits Brian S. Yandell University of Wisconsin-Madison www.stat.wisc.edu/~yandell/statgen [Lan et al. 2003 Genetics 164 (4): August 2003]. what is the goal of QTL study?. uncover underlying biochemistry

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The genetic architecture of crop domestication: a meta-analysis

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QTL mapping in mice

QTL mapping in mice. Lecture 10, Statistics 246 February 24, 2004. The mouse as a model. Same genes? The genes involved in a phenotype in the mouse may also be involved in similar phenotypes in the human. Similar complexity?

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QTL mapping

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Bayesian MCMC QTL mapping in outbred mice

Bayesian MCMC QTL mapping in outbred mice. Andrew Morris, Binnaz Yalcin, Jan Fullerton, Angela Meesaq, Rob Deacon, Nick Rawlins and Jonathan Flint Wellcome Trust Centre for Human Genetics University of Oxford. Motivation.

393 views • 25 slides

Statistical Bioinformatics

Statistical Bioinformatics. QTL mapping Analysis of DNA sequence alignments Postgenomic data integration Systems biology. Statistical Bioinformatics. QTL mapping Analysis of DNA sequence alignments Postgenomic data integration Systems biology. Mixed models for QTL by environment analysis.

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What is a QTL?

What is a QTL?. What are QTL?. Current methods for QTL. Single Marker Methods ( Student, 17?? ) t-tests Interval Mapping Method (Lander and Botstein, Genetics 1989) Mapping: estimate genetic maps Locating QTL: based on genetic map

550 views • 23 slides

Software for Incorporating Marker Data in Genetic Evaluations

Software for Incorporating Marker Data in Genetic Evaluations. Kathy Hanford U.S. Meat Animal Research Center Agricultural Research Service U.S. Department of Agriculture. Outline. Introduction Mixed Models Incorporating Random QTL Effects Current/Future Modification to MTDFREMLQ

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The Role of Epistasis in the Control of Complex Traits

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QTL mapping in mice, cont.

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Ch1 Intro

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Systems model

QTL. QTL. QL. QTL. QTL. Systems model. Phenotype. QTL. QTL. QL. QTL. QTL. Sub-systems model. Phenotype. Genetical Genomics Expression data Genetic variation Pathways underlying complex traits Trait gene identification. X. QTL study AND gene expression study in cross

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11,457 probe sets after normalization

11,457 probe sets after normalization. phenotype of drip loss. general linear model preadjustment. correlation (p<0.001, q<0.004) of 1279 probe sets. 897 eQTL for significantly correlated genes. 104 eQTL in QTL regions for drip loss 96 eQTL with trans regulated acting

114 views • 1 slides