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If fertilization does not occur, the corpus luteum degenerates and breaks down. This degeneration is triggered by the secretion of prostaglandins, which are signaling molecules that initiate this process. As the corpus luteum degrades, the levels of progesterone and estrogen decline, leading to the breakdown of the endometrium. This hormonal shift is crucial for the menstrual cycle, as it prepares the body for the next cycle if pregnancy does not take place.
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No Fertilization…. • Corpus luteum degenerates/breaks down • Degeneration occurs by secreting prostaglandin • Prostaglandin is signaling molecules that triggers the degeneration. • Degeneration of the corpus luteum, levels of progesterone and esterogen declines; endometrium breaks down.