Mucus Hypersecretion and Mucin Synthesis by Airway Epithelial Cells in COPD

1.

2. Mucus Hypersecretion and Mucin Synthesis by Airway Epithelial Cells in COPD

3. Airway Mucus

4. Goblet cell hyperplasia in airway epithelium

5. Definitions: COPD and mucus hypersecretion

6. Role of cough and sputum in the pathogenesis of COPD

8. Is goblet cell hyperplasia associated with COPD or with cigarette smoking ?

9. Effect of cigarette smoke exposure in rat airways

10. Cigarette Smoke

11. Effect of cigarette smoke on neutrophil recruitment in airways

12. Neutrophils and mucin synthesis.

13. Effect of Cigarette smoke on mucin synthesis in NCI-H292 cells

14. Role of EGFR activation in CS-induced mucin synthesis

15. Cigarette smoke induces EGFR activation via an extracellular mechanism

16. EGFR ligands

17. Roles of various EGFR ligands in CS effects on epithelial cells

19. ROS mediates TGF-a release induced by cigarette smoke

21. Effect of EGFR inhibition on cigarette-smoke induced mucus hypersecretion in vivo

22. Induction of goblet cell hyperplasia by cigarette smoke in vivo requires EGFR activation

23. Summary

28. Effect of intranasal fluticasone on mucin MUC5AC and EGFR in nasal polyps

30. Airway mucus (healthy individuals)

33. Cigarette Smoke