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Impact of K65R Mutation on RT·T/PEFdA-MP Binary Complex Formation

This study investigates the effect of the K65R mutation on the formation of the reverse transcriptase (RT) complex with T/PEFdA-MP. Using varying ratios of RT to T/PEFdA-MP, we analyze how the K65R mutation influences complex stability and formation. The results are key to understanding resistance mechanisms in viral replication processes. Additional Figure 1 provides further insights into the complex interactions and ratios examined, illustrating the mutation's role in altering RT functionality and binding dynamics.

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Impact of K65R Mutation on RT·T/PEFdA-MP Binary Complex Formation

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  1. Effect of K65R on formation of RT·T/PEFdA-MP binary complex K65R RT WT RT [RT]:[T/PEFdA-MP] ratios [RT]:[T/PEFdA-MP] ratios 0 0 2 2 3 3 4 4 5 5 6 6 7 7 8 8 9 9 10 10 RT·T/PEFdA-MP RT·T/PEFdA-MP Free T/PEFdA-MP Free T/PEFdA-MP Additional Figure 1

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