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Analysis of HSF1 Mutations and HSP70 Dynamics in Stress Response Mechanisms

This study investigates the impact of various mutations in the Heat Shock Factor 1 (HSF1) gene, particularly the S326A variant, on the regulation of heat shock proteins, with a focus on HSP70. Through a series of experiments, we examine how these mutations affect HSF1 function and its binding to heat shock elements (HSE). The findings provide insights into the molecular mechanisms governing cellular stress responses and suggest potential therapeutic targets for stress-related diseases.

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Analysis of HSF1 Mutations and HSP70 Dynamics in Stress Response Mechanisms

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  1. A C HS S326A B-GAL B-GAL HSF1 HSF1 S326A HSF1/ HSE NS HSF1 B HS C B -GAL B -GAL S326A HSF1 HSF1 S326A HSP70 HSF1 D HSP70 HSF1 HS C C

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