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CHEMICAL TRANSMITTERS

CHEMICAL TRANSMITTERS. The most widely distributed transmitters are acetylcholine (ACH) and noradrenalin . acetylcholine cholinergic nerve cholinergic receptors.

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CHEMICAL TRANSMITTERS

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  1. CHEMICAL TRANSMITTERS The most widely distributed transmitters are acetylcholine (ACH) and noradrenalin. • acetylcholinecholinergic nerve cholinergicreceptors. • noradrenalinadrenergic nerveadrenergic receptors. • adrenergic receptors : there are ά and β receptors, ά receptors are divided into ά1 and ά 2 receptors. • Subtypes of cholinergic receptor are nicotinic and muscarinic receptors.

  2. Acetylcholine Site of release of acetylcholine(the cholinergic nerve fibers): I- Central cholinergic fibers: a)All the preganglionicsympathetic. b) All the preganglionicparasympathetic. c) All the somatic motor fibers supplying the skeletal muscles.

  3. II- Peripheral cholinergic fibers: a) All the parasympathetic postganglionic fibers. b) Sympathetic postganglionic secretary fibers to sweat glands. c) Sympathetic postganglionic vasodilator fibers to blood vessels of skeletal muscle.

  4. Actions of acetylcholine: • "the nicotine-like actions"nicotinic receptors. • "the muscarine-like actions" muscarinic receptors.

  5. Myasthenia Gravis * It is a disease of the neuromuscular junction characterized by weakness and easy fatigability of skeletal musclesautoimmunity. * Destruction of the cell membrane over the motor end plate decreasing the receptor areafor acetyl choline.

  6. Catecholamines Is the chemical transmitter of most of the postganglionic sympathetic nerves. ADRENERGIC RECEPTORS: • There are 2 main types of adrenergic receptors; ά and β. In each type there are 2 subtypes. So, there are ά1, ά2, β1andβ2 adrenergic receptors. • Different adrenergic receptors produce different actions in target organs.

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