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Arterial blood gas analysis. Recording of respiratory + hemodynamic parameters.

NAVA level titration. NAVA level titration. NAVA level titration. NAVA level titration. Study enrolment. Baseline measurements. EMG-ENG, follow up. EMG-ENG, baseline. Stop sedation / NVET. Stop sedation / NVET. Stop sedation / NVET. Stop sedation / NVET. pressure support

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Arterial blood gas analysis. Recording of respiratory + hemodynamic parameters.

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  1. NAVA level titration NAVA level titration NAVA level titration NAVA level titration Study enrolment Baseline measurements EMG-ENG, follow up EMG-ENG, baseline Stop sedation / NVET Stop sedation / NVET Stop sedation / NVET Stop sedation / NVET pressure support ventilation (PSV) Follow up for 48 hrs NAVAal NAVAal NAVAal 48 60 24 36 72 hrs 24 48 hrs bl 0 12  48 hrs Clinical assessment according to the MRC standardized tests of neuro-ventilatory efficiency NVET Figure E1 Arterial blood gas analysis. Recording of respiratory + hemodynamic parameters.

  2. Legend Pat. 1 Pat. 2 Pat. 3 Pat. 4 Pat. 5 Pat. 6 Pat. 7 Pat. 8 Pat. 9 Pat. 11 Pat. 12 Pat. 13 Pat. 14 Figure E2a day 2 day 3 day 1 14 12 10 Tidal volume, ml/kg PBW 8 6 4 2 5 2 0 1 5 Maximum insp. Eadi, V 1 0 5 0 40 30 Resp. rate, bpm 20 10 titrated NAVAAL titrated NAVAAL titrated NAVAAL 0 PSV 0 6 12 end 30 48 60 18 24 36 42 end 54 66 end

  3. Legend Pat. 1 Pat. 2 Pat. 3 Pat. 4 Pat. 5 Pat. 6 Pat. 7 Pat. 8 Pat. 9 Pat. 11 Pat. 12 Pat. 13 Pat. 14 Figure E2b

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