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This overview explains the process of antibody production in response to pathogens in the blood. Macrophages capture pathogens and present their antigens to helper T-cell lymphocytes, which then stimulate B-cells to differentiate into plasma cells. These plasma cells secrete specific antibodies into the blood. The importance of monoclonal antibodies is highlighted, as they are specific in binding to antigens, making them valuable in combating diseases, diagnosing infections, and identifying antigenic molecules effectively.
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Antibody production • Pathogen is in the blood • Macrophages recognise and capture pathogens • Macrophages present their antigens to helper T-cell lymphocytes • Helper T-cell lymphocytes stimulate the appropriate B-cells • Activated B cells differenciate into plasma cells • These plasma cells secretes clones of antibodies into blood • When mission completed helper T cells, B cells, plasma cells, cytotoxic T cells die
Why Monoclonal antibodies? • Antibodies are specific in their binding with antigens. • Developing specific antibodies would be useful in fighting particular diseases, diagnosing infections and identifying molecules with antigenic properties wherever they occur.
