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Understanding the Role of Endocannabinoids and Metabolites in Immune Regulation

This article explores the intricate relationships between endogenous cannabinoids such as AEA, PEA, and OEA, and their receptors, CB1 and CB2, in immune cells. It discusses the metabolic pathways involving FAAH and MAGL enzymes that regulate these compounds and the impact of ethanolamide metabolites on cellular signaling. The interaction with PPAR-α and the influence of inflammatory pathways involving COX2 and TRPV1 are also examined, shedding light on potential therapeutic implications for inflammatory and immune-related disorders.

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Understanding the Role of Endocannabinoids and Metabolites in Immune Regulation

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  1. A. B. extracellular extracellular PEA PEA OEA OEA Nucleus Nucleus AEA AEA 2-AG 2-AG FAAH FAAH FAAH FAAH PPAR- PPAR- COX2/LOX/CYP450 COX2/LOX/CYP450 COX2/LOX/CYP450 COX2/LOX/CYP450 MAGL MAGL AA + Ethanolamide AA + Ethanolamide metabolites metabolites AA + glycerol AA + glycerol intracellular intracellular CB2 CB2 CB1 CB1 TRPV1 TRPV1 Ca2+ Ca2+ Immune Cells COX2 PPAR- CB2

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