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NERVE MUSCLE PHYSIOLOGY

NERVE MUSCLE PHYSIOLOGY. Dr Farzana Salman. OBJECTIVES. At the end of this discussion you should be able to: 1. Know the structural components of a muscle fiber 2. Differentiate striated muscles & correlate it with structural components.

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NERVE MUSCLE PHYSIOLOGY

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  1. NERVE MUSCLE PHYSIOLOGY Dr FarzanaSalman

  2. OBJECTIVES • At the end of this discussion you should be able to: • 1.Know the structural components of a muscle fiber • 2. Differentiate striated muscles & correlate it with structural components. • 3. Know the major types & functions of Proteins present in a muscle fiber

  3. Types of Muscles SimilaritiesDifferences • Skeletal. Excitability. . Structure Contractility . Location • Cardiac. Elasticity. . Function Activation • Smooth. . Contraction

  4. Physiological anatomy of MUSCLE Muscle Fascicle

  5. Physiological anatomy of MUSCLE

  6. SARCOMERE “Structural and functional Unit of the Muscle” Mainly Comprised of: Actin Filaments Arranged between two Z lines Myosin Filaments Besides these ?

  7. SARCOPLASM • Spaces between the myofibrils are filled with intracellular fluid called sarcoplasm. • Potassium • Magnesium • Phosphate • Protein enzymes • Mitochondria

  8. Sarcomere (Supportive Proteins) 1. Titin, 2. Actinin, 3. Desmin & 4. Dystrophin-Glycoprotein complex

  9. SARCOMERE Proteins • Titin: MW= 3 million Largest springy protein Provides scaffolding for the sarcomere Connects Z line to M line • Actinin : MW=190,000 Binds actin to Z line • Desmin: Binds Z line to plasma membrane

  10. Dystrophin-Glycoprotein Complex • Large Protein, MW = 427000 • Forms a Rod which connects the Actin filament to the transmembrane Protein Beta-Dystroglycan in the sarcolema. • Function: Adds strength to the muscle by providing a Scaffolding for the fibrils & connecting them to the Extra cellular Matrix

  11. Dystrophin-Glycoprotein Complex Merosin

  12. CLINICAL SIGNIFICANCE • Musculardystrophies. Diseases that cause progressive weakness of skeletal muscle 1) Duchenne muscular dystrophy. 2) Becker muscular dystrophy.

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