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The renal handling of glucose is a critical process involving the filtration, reabsorption, and excretion of glucose by the kidneys. Under normal physiological conditions, nearly all filtered glucose is reabsorbed in the proximal tubules through sodium-glucose transporters. This process is essential for maintaining glucose homeostasis. However, in conditions such as diabetes mellitus, this balance is disrupted, leading to glucosuria. Understanding the mechanisms of renal glucose handling is vital for developing therapeutic strategies for metabolic disorders.
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