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Liver-derived systemic factors drive beta cell hyperplasia in insulin resistant state.

Liver-derived systemic factors drive beta cell hyperplasia in insulin resistant state. El Ouaamari A, et al. Cell Rep . 2013;3:401-410. Liver insulin receptor knockout. Liver insulin receptor knockout. Insulin resistance. Liver insulin receptor knockout. Insulin resistance. Increased

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Liver-derived systemic factors drive beta cell hyperplasia in insulin resistant state.

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  1. Liver-derived systemic factors drive beta cell hyperplasia in insulin resistant state. El Ouaamari A, et al. Cell Rep. 2013;3:401-410.

  2. Liver insulin receptor knockout

  3. Liver insulin receptor knockout Insulinresistance

  4. Liver insulin receptor knockout Insulinresistance Increased b-cell mass

  5. Liver insulin receptor knockout Insulinresistance Increased b-cell mass b-cell proliferation CTRL LIR KO

  6. Liver insulin receptor knockout Parabiosis CTRL LIR KO Insulinresistance Increased b-cellmass b-cell proliferation CTRL LIR KO

  7. Liver insulin receptor knockout Parabiosis CTRL LIR KO Insulinresistance Increased b-cell mass b-cell proliferation b-cellproliferation CTRL LIR KO CTRL Parabiosis

  8. Liver Insulin receptor knockout Parabiosis CTRL LIR KO Insulinresistance Increased b-cell mass b-cell proliferation b-cellproliferation CTRL LIR KO CTRL Parabiosis LIR KO b-cellproliferation WT islets CTRL Grafted islets

  9. Liver insulin receptor knockout Parabiosis CTRL LIR KO Insulinresistance Increased b-cell mass b-cell proliferation b-cellproliferation CTRL LIR KO CTRL Parabiosis LIR KO Rodent islets Serumfrom LIR KO b-cellproliferation WT islets b-cell proliferation CTRL Grafted islets

  10. Liver insulin receptor knock-out Parabiosis CTRL LIR KO Insulinresistance Increased b-cell mass b-cell proliferation b-cellproliferation CTRL LIR KO CTRL Parabiosis LIR KO Rodent islets Serumfrom LIR KO b-cellproliferation WT islets b-cell proliferation CTRL Grafted islets Human islets

  11. Liver-derived systemic factors drive beta cell hyperplasia in insulin resistant state. El Ouaamari A, et al. Cell Rep. 2013;3:401-410.

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