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Chapter 17 Amino Acid Catabolism

Chapter 17 Amino Acid Catabolism. Excretion as. Urea. Conversion to: pyruvate acetyl- CoA citric acid cycle intermediates. Digestion by proteases. Digestion by proteases. Protein. cytosol. NH 4 +. mitochondria. NH 4 +. Aminotransferases catalyze transfer of amino groups

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Chapter 17 Amino Acid Catabolism

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  1. Chapter 17 Amino Acid Catabolism

  2. Excretion as Urea Conversion to: pyruvate acetyl-CoA citric acid cycle intermediates

  3. Digestion by proteases Digestion by proteases

  4. Protein cytosol NH4+ mitochondria NH4+

  5. Aminotransferases catalyze transfer of amino groups of amino acids to a-ketoglutarate

  6. Predict the product of amino acid catabolism • Alanine??Aspartate?? Glutamate ?? • Draw the structure of each amino acid and then predict the product of the transamination reaction. Hint: count the carbons.

  7. NH3 Chapter 16

  8. Glucose-alaninecycle

  9. Blood Urea Nitrogen (BUN) • Blood urea nitrogen (BUN) measures the amount of urea nitrogen, a waste product of protein metabolism, in the blood. BUN is commonly monitored in hospitals and nursing homes. • Adult BUN: 7-20 mg/100 ml; men may be slightly higher • Predict whether BUN will increase or decrease in the following cases. • Dehydrated patient? Overhydration? • Elderly patient? Newborn? • High protein diet? Malnutrition? • Intestinal bleeding? • Pregnancy? • Kidney failure? Liver failure? • Impaired nutrient absorption?

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