1 / 7

Understanding DNA Mutations: Types, Effects, and Their Impact on Protein Synthesis

This informative article delves into the nature of DNA mutations and their consequences on protein synthesis. It explains various types of mutations including point mutations and frameshift mutations, detailing how even a single base change can alter the resultant protein's structure and function. The article presents examples of original and mutated DNA sequences along with their corresponding mRNA and protein translations, highlighting the importance of DNA integrity for life. The role of mutations in evolution and potential benefits is also discussed, emphasizing the complexity of genetic changes.

cerise
Télécharger la présentation

Understanding DNA Mutations: Types, Effects, and Their Impact on Protein Synthesis

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. DNA : TAC AAA GGA CGA GTA GTT TAA GCA AGA ATT mRNA:AUG UUU CCU GCU CAU CAA AUU CGU UCU UAA Protein: Met-Phe-Pro-Ala-His-Glu-Ile-Arg-Ser-Stop Normal DNA Strand

  2. Mutation • Mutation – Any change in the DNA base sequence which leads to a change in a protein. Sometimes mutation are beneficial, but they usually lead to non-functioning or incorrectly functioning proteins.

  3. Original DNA: TAC AAA GGA CGA GTA GTT TAA GCA AGA ATT Original Protein: Met-Phe-Pro-Ala-His-Glu-Ile-Arg-Ser-Stop 4th triplet in DNA, first base C changed to G Mutated DNA: TAC AAA GGA GGA GTA GTT TAA GCA AGA ATT Incorrect mRNA: AUG UUU CCU CCU CAU CAA AUU CGU UCU UAA Mutated Protein: Met-Phe-Pro-Pro-His-Glu-Ile-Arg-Ser-Stop The 4th amino acid is proline instead of alanine Point Mutation – One base in sequence is changed

  4. Point Mutation

  5. Original DNA: TAC AAA GGA CGA GTA GTT TAA GCA AGA ATT Original Protein: Met-Phe-Pro-Ala-His-Glu-Ile-Arg-Ser-Stop 2nd triplet in DNA, first base A deleted Mutated DNA: TAC AAG GAC GAG TAG TTT AAG CAA GAA TT Incorrect mRNA: AUG UUC CUG CUC AUC AAA UUC GUU CUU AA Mutated Protein: Met-Phe-Leu-Leu-Ile-Lys-Phe-Val-Leu After the second amino acid, the protein is completely different Frameshift Mutation – One base added or deleted from the DNA sequence

  6. Frameshift Mutation

  7. The bottom line about DNA… • No DNA = No Protein = No Cells = No Life • Reproduction is all about passing DNA from one cell to another and from one generation of organisms to the next

More Related