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anti p300 antibody

Rabbit Polyclonal Antibody to Human Acetyl-CBP (Lys1535)/p300 (Lys1499) molecule.<br>https://www.creative-diagnostics.com/Anti-Acetyl-CBP-Lys1535-p300-Lys1499-Antibody-133020-507.htm<br>

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anti p300 antibody

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  1. Anti-Acetyl-CBP/p300 polyclonal antibody (CABT- Anti-Acetyl-CBP/p300 polyclonal antibody (CABT- LM00277) LM00277) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION PRODUCT INFORMATION Product Overview Product Overview Rabbit Polyclonal Antibody to Human Acetyl-CBP (Lys1535)/p300 (Lys1499) molecule Antigen Description Antigen Description CBP (CREB-binding protein) and p300 are highly conserved and functionally related transcriptional co-activators that associate with transcriptional regulators and signaling molecules, integrating multiple signal transduction pathways with the transcriptional machinery. CBP/p300 also contain histone acetyltransferase (HAT) activity, allowing them to acetylate histones and other proteins. Phosphorylation of p300 at Ser89 by PKC represses its transciptional acitivity, and phosphorylation at the same site by AMPK disrupts the association of p300 with nuclear receptors. Ser1834 phosphorylation of p300 by Akt disrupts its association with C/EBPβ. Growth factors induce phosphorylation of CBP at Ser437, which is required for CBP recruitment to the transcription complex. CaM kinase IV phosphorylates CBP at Ser302, which is required for CBP-dependent transcriptional activation in the CNS. The role of acetylation of CBP/p300 is of particular interest. Acetylation of p300 at Lys1499 has been demonstrated to enhance its HAT activity and affect a wide variety of signaling events. Specificity Specificity Acetyl-CBP (Lys1535)/p300 (Lys1499) Antibody detects endogenous levels of CBP or p300 only when acetylated at lysine 1535 or lysine 1499, respectively. Target Target Acetyl-CBP (Lys1535)/p300 (Lys1499) Immunogen Immunogen a synthetic acetylated peptide corresponding to residues surrounding Lys1535 of human CBP Isotype Isotype IgG Source/Host Source/Host Rabbit Species Reactivity Species Reactivity Human Conjugate Conjugate Unconjugated Applications Applications WB, IP, ChIP Sensitivity Sensitivity Endogenous Molecular Weight Molecular Weight 300 kDa Preservative Preservative None 45-1 Ramsey Road, Shirley, NY 11967, USA Email: info@creative-diagnostics.com Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved

  2. Storage Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/ml BSA and 50% glycerol. Store at -20 °C. Warnings Warnings For Research Use Only. Not For Use In Diagnostic Procedures. 45-1 Ramsey Road, Shirley, NY 11967, USA Email: info@creative-diagnostics.com Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved

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