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Supplementary Figure 1

Supplementary Figure 1. CEPH: CYP2C8 (40kb, chr10:96782845..96822844). MAF=0.05. B. Hap-B. Hap-E. Hap-F. Haplotypes above 2%. Hap-A. Hap-D. Hap-C1+C2. Hap-C3. 3´UTR. CYP2C8. Pr. A. JPT+HCB: Asian. YRI: African. Supplementary Figure 2. A. B. C. A. B. C. Hap D (*3). Hap B.

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Supplementary Figure 1

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  1. Supplementary Figure 1 CEPH: CYP2C8 (40kb, chr10:96782845..96822844) MAF=0.05 B Hap-B Hap-E Hap-F Haplotypes above 2% Hap-A Hap-D Hap-C1+C2 Hap-C3 3´UTR CYP2C8 Pr A

  2. JPT+HCB: Asian YRI: African Supplementary Figure 2 A B C

  3. A B C Hap D (*3) Hap B Hap C 20 20 20 18 18 18 16 16 16 * P=0.046 * P=0.036 * P=0.035 14 14 14 12 12 12 Repaglinide AUC (ng h/mL) Repaglinide AUC (ng h/mL) Repaglinide AUC (ng h/mL) 10 10 10 8 8 8 6 6 6 4 4 4 2 2 2 0 0 0 2C8: 2C8: 2C8: Other HapD Other HapD Other HapD Other HapB Other HapB Other HapB Other HapC Other HapC Other HapC SLCO1B1 C-C SLCO1B1 T-C SLCO1B1 T-T SLCO1B1 C-C SLCO1B1 T-C SLCO1B1 T-T SLCO1B1 C-C SLCO1B1 T-C SLCO1B1 T-T Supplementary Figure 3

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