1. Cardio-Sis Incidence of LVH was lower with tight control over usual control (11.4% vs. 17.0%) Composite (death, MI, stroke, TIA, CHF, angina, new AF, revascularization, aortic dissection, PAD, ESRD) was lower with tight control Adverse events, including hypotension, were similar (p = 0.013) (p = 0.003) Trial design:Nondiabetic hypertensive patients with 1 cardiac risk factor were randomized to usual BP control or tight control (SBP <130 mm Hg). Patients were followed for 2 years. Results 9.4 10 20 17.0 % 11.4 5 % 10 4.8 Conclusions • Tight control of SBP (<130 mm Hg) in non-diabetic hypertensive patients with ≥1 CV risk factor was associated with reduced LVH and better outcomes at 2 years than usual control • If confirmed by other trials, current JNC-7 guidelines will need to be revised 0 0 Incidence of LVH Composite endpoint Tight control (n = 558) Usual control (n = 553) Verdecchia P, et al. Lancet 2009;374:525-33