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Touch Receptors and Axons

Touch Receptors and Axons. Lecture 13 PSY391S John Yeomans. Receptors in Skin. Hairy and glabrous skin are different. Sensitivity and Acuity. SS receptors much less sensitive than acoustic or visual receptors. More receptors in glabrous skin of fingertips, lips and genitals.

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Touch Receptors and Axons

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  1. Touch Receptors and Axons Lecture 13 PSY391S John Yeomans

  2. Receptors in Skin Hairy and glabrous skin are different.

  3. Sensitivity and Acuity • SS receptors much less sensitive than acoustic or visual receptors. • More receptors in glabrous skin of fingertips, lips and genitals. • Fewer receptors in back, proximal limbs. • Better 2-point discrimination when more receptors, esp. with small receptive fields.

  4. Adaptation in Single Neurons

  5. Pacinian Corpuscles • Easiest receptor to study due to size and isolation. • Sensitivity high despite deep location when vibratory stimuli used. • Fire at onset and removal of 1 s stimulus--Fast adapting. • Adaptation due to capsule absorbing energy--No adaptation when naked axons are directly stimulated.

  6. Receptive Field Receptive field is part of the environment to which a neuron responds.

  7. Single Neurons in Human Hand • Microelectrodes in nerves isolate single neuron action potentials from large axons. • 4 types of neurons, consistent with 4 receptor types in other animals. • After studying receptive fields and adaptation, then microstimulate single axons to evoke perceptions! • Perceptive fields match receptive fields. Valbo and Johansson

  8. Receptive Fields and Adaptation Glabrous skin of palm and fingertips. Recordings of single axons from median or ulnar nerves. Valbo and Johansson

  9. 4 Different Feelings from Stimulation of Single Axons • Pacinian: No feeling unless >10 action potentials, then “deep vibration”. • Meissner’s: 1 AP leads to “tap”. >10 leads to odd “buzzing” or “fluttering” feeling. • Merkel’s: 4 APs cause “light touch” like leaf. 10 APs cause stronger touch. • Ruffini: No feeling until at least 2 axons, then “tugging” sensation. • Labelled lines for touch sensations.

  10. Axon Types to 100 A alpha

  11. Somatosensory Pathways and Cortex Lecture 14 PSY391S John Yeomans

  12. Dorsal Column Pathway Trigeminal Nucleus V A, Aβ fibers

  13. Dermatomes Trigeminal V Double innervation of each skin area.

  14. Spinothalamic Pathway Parietal postcentral gyrus Trigeminal V

  15. Skin Temperature Sensation Cool-Menthol R1 Vanilloid R1 Vanilloid-like Aδ CMR1, VR1 C fibers

  16. Somatosensory Cortex

  17. Cortex Plasticity in Human

  18. Cortical Layers and Columns Mountcastle

  19. Column Plasticity in Monkey Cut ulnar nerveLose cortical areas

  20. Lesions of SS Cortex • Loss of 2-point discrimination. • Loss of skin temperature discrimination. • Loss of finest sensitivity and motor control.

  21. Association Areas ofPosterior Parietal Cortex • 3D Object Recognition • Body Form (Amorphosynthesis) • Hand-Eye Coordination • Movement and Spatial Perception

  22. Pain and Analgesia Lecture 15 PSY391S John Yeomans

  23. Pain • Acute pain signals tissue damage. • Chronic Pain Syndromes: • Causalgia • Neuralgia • Phantom Limb Pain • Usually involve peripheral nerve damage (neuropathy), but are sustained by CNS. • Hard to treat.

  24. Peripheral Pain Mechanisms

  25. Skin Temperature Sensation Cool-Menthol R1 Vanilloid R1 Vanilloid-like Aδ

  26. Analgesia Pathways

  27. Opiates • Opium, heroin and morphine. • Enkephalins • Endorphins • Dynorphins • Receptors: mu, delta, kappa. • Analgesia, reward, drug abuse.

  28. Muscles and Reflexes Lecture 16 PSY391S John Yeomans

  29. Muscle Types • Smooth muscles in viscera. • Striated muscles to skeleton and connective tissue. • Cardiac muscle--visceral striated muscle with rhythmic contractions. • Fast-twitch and slow-twitch striated muscles.

  30. Muscles

  31. Sliding Filaments

  32. Muscle Fibers and Inputs • Extrafusal fibers with alpha motor neurons. • Intrafusal fibers with gamma motor neurons. • Neuromuscular junction. • Ach release by Ca++. • Nicotinic receptorsEPPsAPs • APsCa++Actin and myosin sliding together.

  33. Neuromuscular Junction

  34. Muscle Receptors

  35. Kinesthetic Receptors • Movements sensed by receptors in muscles, joints and tendons. • Joint receptors respond to angle of joint. • Pacinian corpuscles respond to vibration. • Spindles respond to muscle stretch. • Golgi tendon organs respond to stronger stretch.

  36. Spindle Stretch Receptors

  37. Spindle and Tendon Activation

  38. Proprioceptive Pathways • Spinal reflexes--Monosynaptic stretch. Disynaptic GTO inhibition (clasp-knife). • Dorsal columns to thalamus and motor cortex. • Spinocerebellar path.

  39. Motor Units and Rotation • Motor unit = 1 axon and all the fibres innervated. • Reciprocal inhibition of competing motor units in ventral horn (flexors vs. extensors). • Size principle--small motor units first. • Rotation of motor units, by recurrent inhibition in ventral horn.

  40. Reflexes • Monosynaptic stretch reflex. • Disynaptic tendon reflex (clasp-knife). • Flexion reflex. • Scratching and walking.

  41. Stretch Reflex

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