1. Receptors Anatomic Locations for Nausea Anti-Emetic Medications 5-HT3 D2 M1, H1 GABA Dimenhydrinate Receptor types Receptor types Receptor types Scopolamine Vestibulum Promethazine CNS Prochlorperazine Area Postrema Metoclopramide Click an anatomic location GI Tract Ondansetron Benzodiazepines Corticosteroids Exit Return to this main screen X

2. Receptors Anatomic Locations for Nausea Anti-Emetic Medications M1, H1 Dimenhydrinate Scopolamine Vestibulum Promethazine Dimenhydrinate (Dramamine) is available OTC. The three medications are anticholinergic. X

3. Receptors Anatomic Locations for Nausea Anti-Emetic Medications 5-HT3 D2 M1, H1 GABA Dimenhydrinate Scopolamine Promethazine CNS Prochlorperazine Metoclopramide Ondansetron ↑ intracranial pressure may require corticosteroid tx. Benzodiazepines may be used for psychiatric causes. Benzodiazepines Corticosteroids X

4. Receptors Anatomic Locations for Nausea Anti-Emetic Medications 5-HT3 D2 Prochlorperazine Area Postrema Metoclopramide Ondansetron Opioid receptors are present in the area postrema, which is located at the base of the 4th ventricle X

5. Receptors Anatomic Locations for Nausea Anti-Emetic Medications D2 Promethazine Prochlorperazine Metoclopramide GI Tract Metoclopramide (Reglan) is prokinetic). Promethazine (Phenergan) has more M1/H1-receptor action than D2. Rule out impactions. X

6. Anti-Emetics From Juan Palacios, MD Created by Dan Cushman 2010