Cell Division Process: Understanding DNA, RNA, and Protein Synthesis
E N D
Presentation Transcript
Cell Division • process by which cells reproduce themselves • Includes: - nuclear division -cytoplasmic division • Two types: - somatic cell division - reproductive cell division
Transcription • process by which genetic information encoded in DNA is copied onto a strand of RNA • when strands divide, one strand (the sense strand) acts as the template for mRNA synthesis • the other strand is called the antisense strand
What is DNA? • composed of building blocks called nucleotides • double strand of nucleotides • ladder-like molecule • coiled into a spiral • double helix
DNA Replication • DNA helix uncoils • gradually separates into two nucleotide chains • template for next strand • each nucleotide joins in a complementary sequence
Nucleotide Structure • Composed of: - nitrogenous base - pentose monosaccharide - phosphate groups
Nucleotide Structure (cont.) • nitrogenous base - purines (adenine and guanine) - pyrimidines (cytosine, thymine, and uracil
DNA • DNA bases: - adenine (A) - guanine (G) - cytosine (C) - thymine (T) • adenine (A) bonds with thymine(T) • guanine (G) bonds with cytosine (C)
RNA • RNA bases: - adenine (A) - guanine (G) - cytosine (C) - uracil (U)
Messenger RNA • carries genetic information from DNA to cytosol where it serves as template for protein synthesis
Translation • process by which nucleotide sequence on a strand of mRNA is used as a template for protein synthesis • generates a corresponding amino acid sequence in a polypeptide chain • three consecutive nucleotides are called a codon, which specifies one amino acid
Somatic Cell Division • results in an increase in number of cells in body (growth, repair) • Cell life cycle has two major periods: - interphase (resting stage) - mitotic phase (cell division reproduction occurs)
Interphase • series of activities before reproduction • between divisions • each chromosome makes copy of self • two identical chromosomes • chromatids are united by centromere • metabolic activities continue • longest phase of the cell cycle • very active
Cell Division • Process includes: - mitosis nuclear division formation of two daughter nuclei - cytokinesis division of cytoplasm begins once mitosis is nearly complete
Stages of Mitosis • prophase • metaphase • anaphase • telophase
Prophase (pro = before) • chromosomes become visible as chromatids • nucleolus disappears • mitotic spindle appears
Prophase (cont.) • chromatin threads coil and shorten into chromosomes - double stranded (chromatids) • each chromatid is held together by small median body called a centromere • centrosome and its centrioles each move to opposite sides of cell
Prophase (cont.) • mitotic spindle between centrioles (responsible for attachment and movement of chromosomes) • end of stage - nuclear membrane and nucleoli have broken down and disappeared • chromosomes are randomly attached to centromeres by spindle fibers
Prophase Prophase 2 Prophase 1
Metaphase (meta = after) • short • chromosome pairs line up on the metaphase plate (exact midpoint or center of the mitotic spindle) • straight line of chromosomes
Anaphase (ana=upward) • centromeres divide and separate • identical chromosomes move to opposite poles with centromeres
Telophase (telo = far or end) • begins as soon as chromosomal movement stops • chromosomes at poles uncoil • resume chromatin form (threadlike) • nuclear membrane forms around each chromatin mass • nucleoli reappear • mitotic spindle disappears
Cytokinesis(kinesis = motion) • division of cytoplasm and organelles • occurs in late anaphase • furrow develops and progresses inward dividing cell into two separate portions of cytoplasm
Conclusion • two daughter cells genetically identical to the original mother cell • each cell diploid in number
Meiosis • cell division • restricted to sex cell (gametes) production • involves two successive nuclear divisions • results in daughter cells with haploid (1/2) number of chromosomes
Haploid • one half the normal number of chromosomes (23 in humans) Diploid • number of chromosomes characteristically found in somatic cells of an organism (46 in humans)