Download
amino acids n.
Skip this Video
Loading SlideShow in 5 Seconds..
Amino acids PowerPoint Presentation
Download Presentation
Amino acids

Amino acids

291 Vues Download Presentation
Télécharger la présentation

Amino acids

- - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript

  1. Amino acids • Met dank aan Dr. Detke

  2. Most amino acids are chiral • All naturally occuring amino acids except Gly are the L isomer • L & D amino acids are stereoisomers

  3. Most amino acids are zwitterions • amino acids are zwitterions at neutral pH (contains negative and positive charged groups)

  4. Glycine non-chiral smallest most flexible in polypeptides less hydrophobic Alanine chiral next smallest less hydrophobic Small aliphatic amino acids

  5. Val, Leu, Ile Highly hydrophobic branched side-chains Other aliphatic amino acids

  6. Proline imino acid rigid ring structure puts kinks in polypeptides Yet another aliphatic amino acid

  7. Aromatic amino acids • Phenylalanine • Absorbs UV • Very hydrophobic • Tyrosine • Absorbs UV • less hydrophobic • H-bonds • OH can ionize • OH can be modified • Tryptophan • Really absorbs UV! • less hydrophobic • H-bonds

  8. Methionine highly hydrophobic initiator amino acid Cysteine less hydrophobic forms disulfide bonds SH group can ionize Sulfur-containing amino acids

  9. Disulfide bond formation is reversible Disulfide bonds form in proteins and help stabilize their structures Oxidation of cysteine to cystine

  10. Ser, Thr less hydrophobic H-bonding potential can be modified Thr is an isostere of Val Alcoholic amino acids

  11. Asp, Glu highly hydrophilic negatively charged at neutral pH Acidic amino acids

  12. Highly hydrophilic Lys and Arg are positively charged at neutral pH His is partially charged at neutral pH Basic amino acids

  13. Asn, Gln highly hydrophilic H-bonding potential isosteres of Asp and Glu Amide-containing amino acids

  14. Peptide bond formation

  15. The peptide bond is planar Fig. 4.6

  16. Aspartame – a dipeptide 200X Sweeter than Sucrose !!! aspartylphenylalanine methyl ester