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Targeting Plasmodium Aspartic Proteases for Innovative Antimalarial Drug Development

Our research focuses on the Plasmodium aspartic proteases (Plasmepsins) as crucial targets for developing new antimalarial drugs. We investigate the PEXEL signal, which facilitates protein export in Plasmodium, and the role of PMV protease in cleaving PEXEL sequences necessary for the parasite's survival. The main goal is to design potent small molecule PMV inhibitors to enhance understanding of the malaria export pathway and ultimately develop effective antimalarial treatments. This project has implications for combating malaria, a leading global health challenge.

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Targeting Plasmodium Aspartic Proteases for Innovative Antimalarial Drug Development

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  1. R1-R10 : Dr. Example Research Photo Research Title Research area Write down your research details etc Put any figures relating to your work fscixxx@ku.ac.th Our work shows…………………………. The main goal of this project is to……………………………………………………………. Research title Research area Put any figures relating to your work Our work shows…………………………. The aim of this project is to……………………………………………………

  2. R4: Assist. Prof. NonlawatBoonyalai Plasmodium aspartic proteases (Plasmepsins) as antimalarial drug targets Antimalarial Drug Discovery: Plasmodium export element (PEXEL) signal RxLxE/D/Q downstream of the signal peptide is known to export proteins to the erythocyte. PEXEL motif is proteolytically cleaved after the RxL in the ER, to generate xE/D/Q at the N-terminus. fscinwb@ku.ac.th PMV is necessary for parasite viability and is the protease responsible for cleavage of the PEXEL sequence and ensuring protein export. The main goal of this project is to design potent small molecule PM V inhibitors that will help to further probe the biology of the malaria parasite’s export pathway and, ultimately, to generate a new antimalarial drug. Inhibitory mechanism study of human Topoisomerase II by naphthoquinone derivatives Anticancer Drug Discovery: IC50 = 15.16 μM IC50 = 1.76 μM The objective of this project is to develop an understanding of the binding mode of drug by investigating the interactions, complex structures and biophysical properties of Topoisomerase II and rhinacanthins derivatives. We are also interested in evaluating other Topoisomerase II inhibitors.

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