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Toxicological interactions between the mycotoxins deoxynivalenol , nivalenol and their acetyl derivatives in intestinal epithelial cells Archives of Toxicology Imourana Alassane-Kpembi , Olivier Puel and Isabelle P. Oswald

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Online Resource 1

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  1. Toxicological interactions between the mycotoxinsdeoxynivalenol, nivalenol and their acetyl derivatives in intestinal epithelial cells Archives of Toxicology ImouranaAlassane-Kpembi, Olivier Pueland Isabelle P. Oswald Corresponding author: Isabelle P. OSWALD, INRA, UMR 1331 Toxalim, Research Center in Food Toxicology, 180 chemin de Tournefeuille, BP93173,31027 Toulouse cedex 03,FRANCE. Isabelle.Oswald@toulouse.inra.fr, Tel: 33 (0) 5 61 28 54 80

  2. Online Resource 1 Online Resource 1 : Chemical structures of DON and NIV and their acetyl derivatives 140

  3. Online Resource 2 Online Resource 2 : Comparative toxicity of individual mycotoxins on proliferating IPEC-1 cells. Intestinal epithelial cells were exposed for 24 hours to serial dilutions of toxins. Cytotoxicity was assessed by the MTT assay. Data are means ± SD of three independent experiments.

  4. Online Resource 3 5 2.5 50% cytotoxicity 30% cytotoxicity 10% cytotoxicity DON (µM) 0 0 1.5 3 15-ADON (µM) Online Resource 3: Isobologram illustrating the combined cytotoxicity of DON and 15-ADON at concentrations eliciting 10% ( ), 30% ( ) or 50% () toxicity. The points are mean concentrations of dose-response MTT test cytotoxicity curves for each toxin or toxin combination (Compusyn software analysis).

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