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Toxicological Interactions of Mycotoxins in Intestinal Cells

Study on interactions between deoxynivalenol, nivalenol, and their acetyl derivatives in intestinal epithelial cells. Evaluates cytotoxicity using MTT assay. Published in Archives of Toxicology.

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Toxicological Interactions of Mycotoxins in Intestinal Cells

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  1. Toxicological interactions between the mycotoxinsdeoxynivalenol, nivalenol and their acetyl derivatives in intestinal epithelial cells Archives of Toxicology ImouranaAlassane-Kpembi, Olivier Pueland Isabelle P. Oswald Corresponding author: Isabelle P. OSWALD, INRA, UMR 1331 Toxalim, Research Center in Food Toxicology, 180 chemin de Tournefeuille, BP93173,31027 Toulouse cedex 03,FRANCE. Isabelle.Oswald@toulouse.inra.fr, Tel: 33 (0) 5 61 28 54 80

  2. Online Resource 1 Online Resource 1 : Chemical structures of DON and NIV and their acetyl derivatives 140

  3. Online Resource 2 Online Resource 2 : Comparative toxicity of individual mycotoxins on proliferating IPEC-1 cells. Intestinal epithelial cells were exposed for 24 hours to serial dilutions of toxins. Cytotoxicity was assessed by the MTT assay. Data are means ± SD of three independent experiments.

  4. Online Resource 3 5 2.5 50% cytotoxicity 30% cytotoxicity 10% cytotoxicity DON (µM) 0 0 1.5 3 15-ADON (µM) Online Resource 3: Isobologram illustrating the combined cytotoxicity of DON and 15-ADON at concentrations eliciting 10% ( ), 30% ( ) or 50% () toxicity. The points are mean concentrations of dose-response MTT test cytotoxicity curves for each toxin or toxin combination (Compusyn software analysis).

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