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Somatosensory System and Pain

08-9 פיסיולוגיה מורחב. Somatosensory System and Pain. lecture 6: Ascending pathways. Prof. Marshall Devor, Ph.D. Dept. of Cell & Animal Biology and Center for research on Pain Institute of Life Sciences Hebrew University of Jerusalem. perception vs. regulation. primary sensory

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Somatosensory System and Pain

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  1. 08-9 פיסיולוגיה מורחב Somatosensory System and Pain lecture 6: Ascending pathways Prof. Marshall Devor, Ph.D. Dept. of Cell & Animal Biology and Center for research on Pain Institute of Life Sciences Hebrew University of Jerusalem

  2. perception vs. regulation primary sensory neurons

  3. antero- lateral column Spinal white matter pathways dorsal column

  4. dorsal column – medial lemniscus system hand A LTM afferents foot

  5. somatosensory cortex (S1) thalamus (ventro-basal nucleus) VPL, VPM dorsal column nuclei dorsal column – medial lemniscus system light touch and vibration sense

  6. hand foot anterolateral column system (spino-bulbo-thalamic system) all types of afferents

  7. somatosensory cortex (S1) thalamus (ventro-basal nucleus) VPL, VPM brainstem nuclei "bulbo-" spino-bulbo-thalamic system which sense ?

  8. spino-bulbo- thalamic system

  9. tabes dorsalis dorsal column – medial lemniscus system light touch and vibration spino-bulbo-thalamic system which sense ??

  10. hand foot anterolateral column system (spino-bulbo-thalamic system) all types of afferents

  11. dorsal column – medial lemniscus system light touch and vibration spino-bulbo-thalamic system all somato-visceral senses

  12. primary sensory neurons • “medial pain pathway” • lamina I (nociceptive) •  parabrachial n. (pons) • amygdala + hypothalamus

  13. barrel field (van der Loos) succinyl dehydrogenase

  14. homunculus

  15. functional magnetic resonance imaging fMRI

  16. anterior cingulate gyrus saggital human brain

  17. CCoghill et al. 2003 constant stimulus, variable sensory response among subjects

  18. propriospinal system propriospinal tract

  19. פיסיולוגיה מורחב Somatosensory System and Pain lecture 6: Ascending pathways Prof. Marshall Devor, Ph.D. Dept. of Cell & Animal Biology and Center for research on Pain Institute of Life Sciences Hebrew University of Jerusalem

  20. primary sensory neurons

  21. P P A A Q Q • heterogeneity of primary afferents (labeled line theory) • divergence + convergence  different heterogeneity of second • order projection neurons • (2x specific, WDR, multireceptive) • dynamic (RF size & response properties, central sensitization ) • multiple ascending pathways • multiple terminal areas • descending control (feedback, feedforward, anticipation) "Population activity theory" “bottom-up” vs. “top-down” for every unique stimulus, a unique constellation of neural population activity

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