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Chromosome

This study explores alterations in protein-coding genes by comparing tumor samples to normal samples, highlighting key mutations affecting the PIK3CA gene (N202Y, E545K), along with other relevant mutations in ROS1 and KIT genes. The supplemental figures provide detailed assessments of mutation frequencies, binding domains, and various genomic alterations observed in Small Cell Lung Cancer (SCLC) samples. Key insights include the implications of these mutations on tumor behavior and potential therapeutic targets.

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Chromosome

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  1. Supplemental Figure 1 Tumor samples Normal samples Chromosome

  2. Supplemental Figure 2 B A Percent Number of protein altering mutations Samples

  3. Supplemental Figure 3 PIK3CA N202Y E545K T313R p85 binding domain Ras binding domain C2 domain Helical domain Kinase domain V317- **Y155H PTEN S287* Phos- phatase domain C2 domain

  4. Rev. Supplemental Figure 4 SCLC 042 PIK3CA(Vf*: 46.7%) genome_mut_syntax: g.3:178919119A>T aa_mut_syntax: p.N202Y (Substitution-Missense) SCLC 038 Rev. PIK3CACOSMICid: 764 (Vf*: 60.7%) genome_mut_syntax: g.3:178936091G>A aa_mut_syntax: p.E545K (Substitution-Missense) SCLC 058 ROS1(Vf*: 41.2%) genome_mut_syntax: g.6:117641077C>T aa_mut_syntax: p.V1965A (Substitution-Missense) SCLC 018 Rev. ROS1(Vf*: 11.5%) genome_mut_syntax: g.6:117631325C>A aa_mut_syntax: p.R2118I (Substitution-Missense) SCLC 024 KIT(Vf*: 60.0%) genome_mut_syntax: g.4:55589771_3 ACG del aa_mut_syntax: p.Y418del (Deletion-In frame)

  5. Supplemental Figure 5 A B Chromosome Chromosome GISTICq score GISTICq score

  6. Supplemental Figure 6

  7. Supplemental Figure 7 A B C

  8. Supplemental Figure 8 A B C PIK3CA p-AKT AKT p-S6RP S6RP GAPDH siNC #1 #2 #3 siPIK3CA

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