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Supplementary Table 1 Sequences of quantative RT-PCR primers

Supplementary Table 1 Sequences of quantative RT-PCR primers. Supplementary Table 2 Body weight, plasma parameters and blood pressure of E-DNI  B mice. Supplementary Table 3 Body weight and plasma parameters of E-DNI  B mice. Supplementary Figure 1. Lung. Aorta. Macrophages.

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Supplementary Table 1 Sequences of quantative RT-PCR primers

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  1. Supplementary Table 1 Sequences of quantative RT-PCR primers

  2. Supplementary Table 2 Body weight, plasma parameters andblood pressure of E-DNIB mice

  3. Supplementary Table 3 Body weight and plasma parameters of E-DNIB mice

  4. Supplementary Figure 1 Lung Aorta Macrophages Dominant negative IkB human IB (38kDa) 40 Endogenous mouse IkBa (36kDa) 35 - - - + + + Transgene: (kDa)

  5. 800 600 400 200 0 Supplementary Figure 2 A wild-type E-DNIB Dominant negative IkB human IB (38kDa) Endogenous mouse IkBa (36kDa) TNF-: (g/kg body WT) 0 1 5 10 0 1 5 10 B C 300 Relative amount of IL-6 mRNA () in TNF-stimulated isolated macrophages 200 Relative amount of VCAM-1 mRNA () in TNF-stimulated isolated endothelial cells 100   0 TNF-: (ng/ml) TNF-: (ng/ml) 0 10-1 100 101 0 10-1 100 101

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