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Probabilistic functional maps of human subcortical structures

Probabilistic functional maps of human subcortical structures. Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore Alim Louis Benabid, MD, PhD University of Joseph Fourier School of Medicine, Grenoble, France www.ibe.a-star.edu.sg www.cerefy.com.

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Probabilistic functional maps of human subcortical structures

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  1. Probabilistic functional maps of human subcortical structures Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore Alim Louis Benabid, MD, PhD University of Joseph Fourier School of Medicine, Grenoble, France www.ibe.a-star.edu.sg www.cerefy.com

  2. Outline • BIL Neuroinformatics R&D roadmap • About brain atlas • atlas definition • atlas applications • Anatomical brain atlases and applications • Probabilistic functional maps • source data • construction • Functional atlas applications • neuroscience research • Internet portal for functional neurosurgery

  3. BIL Neuroinformatics R&D roadmap Human brain atlases Atlas-based applications BIL Neuroinformatics Registration Brain segmentation Brain databasing

  4. Atlas applications • Stereotactic and functional neurosurgery • Human brain mapping • Neuroradiology • Neuroeducation • Neurosurgical training • Analysis of brain images • Neuroscience research • Drug testing • Gene expression mapping • Laymen education

  5. Brain LAB’sTarget Atlas inside Cerefy Products Cerefy brain atlas Stereotactic and functional neurosurgery (5 products) (130 surgical workstations; 1,500 clinical individuals) Electronic Brain Atlas Library Brain Atlas Geometrical Models Cerefy Probabilistic Functional Atlas Cerefy SFN Portal Medtronic/Sofamor Danek’s Stealth Station SurgiPlan Elekta (Sweden) SNN3 IGS SNN/Cedara (Canada) NeuroMate ISS (USA/France)

  6. Cerefy brain atlasBrain mapping, neuroradiology, neuroeducation (4 products) Mayo’s Analyze Atlas inside Cerefy Products Cerefy Neuroradiology Atlas (430 subscribers from www.cerefy.com) Cerefy Student Brain Atlas The Cerefy Atlas of Brain Anatomy (450 copies)

  7. Limitations of current atlases - sparse atlas plates constructed from a few specimens only - atlases are anatomical while the stereotactic targets are functional

  8. PFA construction • constructed from electrophysiological and neuroimaging data • reconstruct 3D data from projections • normalize contact data • select best contacts • voxelize contacts • calculate atlas (best contact frequency) • compute probability

  9. PFA applications - Neuroscience research - Stereotactic and functional neurosurgery

  10. Summary • Probabilistic functional atlas overcomes several limitations of the current anatomical atlases • Facilitates knowledge discovery • Paradigm shift from manufacturer-centric to community centric

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