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Organ-System-Based Integration of Biochemistry: Cells Do It; Can We Do It as Well?

cytoskeleton/extracellular matrix. extracellular/intracellular communications. proteins/enzymes. hemostasis/thrombosis. nutrition. bioenergetics/metabolism. informational macromolecules. Organ-System-Based Integration of Biochemistry: Cells Do It; Can We Do It as Well?.

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Organ-System-Based Integration of Biochemistry: Cells Do It; Can We Do It as Well?

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  1. cytoskeleton/extracellular matrix extracellular/intracellular communications proteins/enzymes hemostasis/thrombosis nutrition bioenergetics/metabolism informational macromolecules Organ-System-Based Integration of Biochemistry: Cells Do It; Can We Do It as Well? http://www.ebi.ac.uk/microarray/biology_intro.html Eric Niederhoffer Southern Illinois University School of Medicine

  2. Clinical Sciences Basic Sciences Y1 (Carbondale) Y2 Y3 clerkships Y4 electives Organ-System-Based Integration of Biochemistry CRR SSB ERG HII C NB ERG Anatomy BSS Biochemistry Doctoring Genetics Histology Pharmacology Physiology PHP Doctoring Genetics Immunology Microbiology Neoplasia Pathology Pharmacology Radiology

  3. Overview of gene expression Genetics MC Collagen/anemia Hb gene/product/defect SCD RBC structure Surfactant SOB MC Glycolysis/2,3-BPG, PPP/GSH HbO2/CO2 Lifestyle MC Nutrition ASD Chem panels PE Coagulation/clinical markers Familial hyperlipidemia nutrition/metabolism CVD MC COPD ECM/proteases/antiproteases/1AT Ion channels/action potentials Clinical markers Arrhythmia G proteins/signal transduction F&E MC G proteins/ signal transduction Cholesterol/lipoproteins/plaques/lipid processing Cardiac markers G proteins/ signal transduction MI Shock MC Thrombolytic agents Muscle contraction/energy production Filtration barrier PSGN Amino acid processing/urea cycle SAQs (mc, T/F, short answers) Ion channels/membrane transport Electrolyte imbalance Clinical markers MU & EOU Exams (clinical scenarios) ATP production CHF Clinical markers/BNP CRR Unit Organization

  4. Sickle Cell Disease Introduction to genetics (basic principles) Introduction to molecular biology of gene expression: transcription, translation, protein processing Hemoglobin structure: HbA (22), HbF (22), HbA2 (22), HbS; overview of hemoglobin function Complete blood count: RBC parameter (Hct, Hb content, MCV, MCHC) and WBCs Red blood cells: structure and function, glycolysis (2,3-BPG), pentose phosphate pathway, glutathione Structure and function of the spleen Pathogenesis and natural history of sickle cell disease Introduction to child development: Denver development chart, normal milestones Introduction to immunology: cause of inflammation and pain (cytokines and phagocytes) ePBLM Organization

  5. Worst Features Best Features low priority Integration with other disciplines/clinical medicine Perceived orphan topics overlap/redundancy of topics Competition with other disciplines clinical relevance Non-biochemistry resources The Best and Worst at Times

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