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Bioreactor Scale-Up and CFD Review 12

What is Scale-Up?. To take a manufacturing process from the laboratory scale to a desired large scale at which it is commercially feasible.3 StagesBench Scale ( 2

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Bioreactor Scale-Up and CFD Review 12

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    1. Rob Levine Bioreactor Scale-Up and CFD Review 12/3/10

    2. What is Scale-Up? To take a manufacturing process from the laboratory scale to a desired large scale at which it is commercially feasible. 3 Stages Bench Scale ( 2 20 L) Pilot Scale (100 500 L) Plant Scale (500 20,000 L)

    3. Scale-Up Parameters Geometry Height to Diameter Ratio is held constant Called aspect ratio

    4. Scale-Up Parameters Agitation-based parameters Mixing time Power input per Volume (P/V) Tip Speed Gassing-based parameters Vessel Volumes per Minute (VVM) Superficial Gas Velocity (Vs) NOTE: Cannot keep all parameters constant during scale up because they scale by different values

    5. Agitation Parameters

    6. Gassing Parameters

    7. Scale-Up Review Overall, scaling up process parameters is tricky Each scale-up parameter is dependent on another Cannot keep all constant during scale-up Not one scale-up process is correct Technicians determine which parameter is critical to the process and try to find a happy medium between each of the remaining parameter

    8. Computational Fluid Dynamics (CFD) The prediction of fluid flow, heat, mass, and momentum transfer, chemical reactions, and related phenomena in a model system. Utilizes computer power to process the differential equations that have been developed to describe a model of a system

    9. CFD Modeling/Meshing Once the model is generated using CAD software, next have to partition into a mesh that will provide the best resolution for the fluid flow Ensure adequate resolution in the most dynamic regions Comes at a cost of computing capability

    10. CFD Solves Scale-Up Issues Many facilities dont have the space or time to calculate/run experiments for scale-up Companies model the equations and the CFD results model the systems digitally

    11. Pros and Cons of CFD

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