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Multilevel activation of STAT3 by KIF5B-RET fusion kinase in lung cancer

This study demonstrates the promotion of cell growth in lung cancer by the KIF5B-RET fusion kinase through multilevel activation of STAT3. RT-PCR analysis and direct sequencing validate the presence of the KIF5B-RET fusion gene in lung cancer patients.

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Multilevel activation of STAT3 by KIF5B-RET fusion kinase in lung cancer

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  1. Supplementary Data KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer

  2. Figure S1 (related to Figure 1). B. Marker 21# T 21#N KIF5B exon 15 RET exon 12 A. 2000 1000 750 500 250 100 Figure S1. (A) Detection of KIF5B-RET fusion by RT-PCR analysis in NO.21 patient among 100 Chinese LAD patients. The KIF5B-RET fusion gene was detected by RT-PCR. One LAD positive for KIF5B-RET fusions (T) is shown, with its corresponding noncancerous lung tissues (N). (B) KIF5B exon 15 fused to RET exon 12 (K15; R12) were validated by direct sequencing. The fusion point of KIF5B-RET is shown.

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